Evidence map›Paper›PMID 34229586›Full record

ArticleCell cycle (Georgetown, Tex.)2021

Platelet-rich plasma attenuates intervertebral disc degeneration via delivering miR-141-3p-containing exosomes.

Jiayuan Xu, Guangying Xie, Weiliang Yang, Wantao Wang, Zhuan Zuo, Wenbo Wang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  18. [Mechanism of extracellular vesicles in the repair of intervertebral disc degeneration].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jiayuan XuDepartment of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Guangying XieDepartment of Blood Transfusion, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Weiliang YangDepartment of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Wantao WangDepartment of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhuan ZuoDepartment of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Wenbo WangDepartment of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, Harbin, China.ORCID 0000-0001-5501-1039
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress mediated apoptotic and pyroptotic cell death contributes to intervertebral disc (IVD) degeneration, and platelet-rich plasma (PRP) exerts protective effects to attenuate IVD degeneration. Hence, the present study aimed to validate this issue and uncover the potential underlying mechanisms. The mice and cellular models for IVD degeneration were established by using puncture method and H

Indexed as

Oxidative StressPyroptosisAnimalsAntioxidantsCells, CulturedDisease Models, AnimalExosomesIntervertebral Disc DegenerationKelch-Like ECH-Associated Protein 1MaleMiceMice, Inbred C57BLMicroRNAsNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinNucleus PulposusAntioxidantsKeap1 protein, mouseKelch-Like ECH-Associated Protein 1MicroRNAsMirn141 microRNA, mouseNfe2l2 protein, mouseNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseexosomesintervertebral disc degenerationKeap1-Nrf2 pathwaynucleus pulposusOxidative stress

Identifiers

PMID34229586
PMCPMC8354670
OpenAlexW3178643910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.