Evidence map›Paper›PMID 34229558›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1

Jun Wu, Hongyu Hu, Mingtao Ao, Zhenzhen Cui, Xiaoping Zhou, Jingbo Qin, Yafei Guo, Jingwei Chen, Yuhua Xue, Meijuan Fang

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. A Review on Medicinal Approaches of Novel Imatinib Derivatives.Current topics in medicinal chemistry · 2025
    Review
  4. Review
  5. Surveying the landscape of emerging and understudied cell death mechanisms.Biochimica et biophysica acta. Molecular cell research · 2023
    Review
  6. Methuosis Contributes to Jaspine-B-Induced Cell Death.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jun WuSchool of Pharmaceutical Sciences and School of Public Health, Xiamen University, Xiamen 361102, China.
Hongyu HuXingzhi College, Zhejiang Normal University, Lanxi, China.
Mingtao AoSchool of Pharmaceutical Sciences and School of Public Health, Xiamen University, Xiamen 361102, China.
Zhenzhen CuiSchool of Pharmaceutical Sciences and School of Public Health, Xiamen University, Xiamen 361102, China.
Xiaoping ZhouSchool of Pharmaceutical Sciences and School of Public Health, Xiamen University, Xiamen 361102, China.
Jingbo QinSchool of Pharmaceutical Sciences and School of Public Health, Xiamen University, Xiamen 361102, China.
Yafei GuoSchool of Pharmaceutical Sciences and School of Public Health, Xiamen University, Xiamen 361102, China.
Jingwei ChenSchool of Pharmaceutical Sciences and School of Public Health, Xiamen University, Xiamen 361102, China.
Yuhua XueSchool of Pharmaceutical Sciences and School of Public Health, Xiamen University, Xiamen 361102, China.
Meijuan FangSchool of Pharmaceutical Sciences and School of Public Health, Xiamen University, Xiamen 361102, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study describes the synthesis and vacuole-inducing activity of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1

Indexed as

Drug DesignAnimalsAntineoplastic AgentsApoptosisCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorEndoplasmic ReticulumHumansHydrazinesMammary Neoplasms, ExperimentalMiceModels, MolecularMolecular StructureStructure-Activity RelationshipAntineoplastic AgentscarbohydrazideHydrazines1H-indole-2-carbohydrazide derivativesAnticancer agentMDA-MB-231 cellsMethuosis

Identifiers

PMID34229558
PMCPMC8266240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.