Evidence map›Paper›PMID 34229511›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Persistent CO

Limin Wu, Suk-Tak Chan, William J Edmiston, Gina Jin, Emily S Levy, Kenneth K Kwong, Rebekah Mannix, William P Meehan, Fortunate F Chifamba, Jonathan O Lipton and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Phosphodiesterase-5 (PDE-5) Inhibitors as Therapy for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Limin WuDepartment of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Suk-Tak ChanDepartment of Radiology, A. Martino's Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
William J EdmistonDepartment of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gina JinDepartment of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Emily S LevyDepartment of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Kenneth K KwongDepartment of Radiology, A. Martino's Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Rebekah MannixDepartment of Emergency Medicine, Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
William P MeehanDepartment of Emergency Medicine, Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Fortunate F ChifambaDepartment of Neurology, Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Jonathan O LiptonDepartment of Neurology, Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Michael J WhalenDepartment of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yin-Ching I ChenDepartment of Radiology, A. Martino's Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Mechanisms of cognitive dysfunction after repetitive closed head injury in adolescent miceR01NS096550 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WHALEN, MICHAEL J · 2018 to 2021
$1.4M
NICHD NIH HHS P50 HD105351NINDS NIH HHS R01 NS096550
6 · The paper itself

Abstract

Cerebrovascular reactivity (CVR) deficits in adolescents with concussion may persist after resolution of neurological symptoms. Whether or not CVR deficits predict long term neurological function is unknown. We used adolescent mice closed head injury (CHI) models (54 g, 107 cm or 117 cm drop height), followed by blood oxygenation level dependent (BOLD)-functional MRI with CO

Indexed as

Cerebrovascular CirculationAnimalsBrain ConcussionCarbon DioxideDisease Models, AnimalMaleMiceCarbon DioxideAdolescentcerebrovascular reactivityfMRImild traumatic brain injuryneurological dysfunction

Identifiers

PMID34229511
PMCPMC8669283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.