Evidence map›Paper›PMID 34228922›Full record

ArticleAnalytical chemistry2021

Mass Spectrometry Imaging of Lipids with Isomer Resolution Using High-Pressure Ozone-Induced Dissociation.

Britt S R Claes, Andrew P Bowman, Berwyck L J Poad, Reuben S E Young, Ron M A Heeren, Stephen J Blanksby, Shane R Ellis

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 85 citations in OpenAlex.

  1. Aziridination-Enabled Structural and Quantitative Lipidomics.Journal of the American Society for Mass Spectrometry · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Analytical applications of gas-phase ion chemistry enabled by mass spectrometry.Analytical methods : advancing methods and applications · 2026
    Review
  8. Review
  9. Structural Elucidation of Phosphatidylcholines via Radical-Directed Dissociation of [M + CuJournal of the American Society for Mass Spectrometry · 2025
    Article
  10. Article
  11. Article
  12. Mass Spectrometry Imaging.Analytical chemistry · 2025
    Review
  13. Article
  14. Spatial mapping of phosphatidylcholineInternational journal of mass spectrometry · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Quantitative mass spectrometry imaging: therapeutics & biomolecules.Chemical communications (Cambridge, England) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Britt S R ClaesThe Maastricht MultiModal Molecular Imaging (M4I) institute, Division of Imaging Mass Spectrometry (IMS), Maastricht University, 6229 ER Maastricht, The Netherlands.
Andrew P BowmanThe Maastricht MultiModal Molecular Imaging (M4I) institute, Division of Imaging Mass Spectrometry (IMS), Maastricht University, 6229 ER Maastricht, The Netherlands.
Berwyck L J PoadCentral Analytical Research Facility, Queensland University of Technology, Brisbane, Queensland 4001, Australia.ORCID 0000-0002-0420-6116
Reuben S E YoungSchool of Chemistry and Physics, Queensland University of Technology, Brisbane, Queensland 4001, Australia.
Ron M A HeerenThe Maastricht MultiModal Molecular Imaging (M4I) institute, Division of Imaging Mass Spectrometry (IMS), Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-6533-7179
Stephen J BlanksbyCentral Analytical Research Facility, Queensland University of Technology, Brisbane, Queensland 4001, Australia.ORCID 0000-0002-8560-756X
Shane R EllisThe Maastricht MultiModal Molecular Imaging (M4I) institute, Division of Imaging Mass Spectrometry (IMS), Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-3326-5991
Maastricht University · NLQueensland University of Technology · AUUniversity of Wollongong · AU

Funding

Hypoxia-derived molecular MSI signatures to predict breast cancer outcomeR01CA213492 · NCI · JOHNS HOPKINS UNIVERSITY · PI GLUNDE, KRISTINE, HEEREN, RON · 2017 to 2021
$2.1M
NCI NIH HHS R01 CA213492
6 · The paper itself

Abstract

Mass spectrometry imaging (MSI) of lipids within tissues has significant potential for both biomolecular discovery and histopathological applications. Conventional MSI technologies are, however, challenged by the prevalence of phospholipid regioisomers that differ only in the location(s) of carbon-carbon double bonds and/or the relative position of fatty acyl attachment to the glycerol backbone (

Indexed as

OzoneGlycerolIsomerismLipidsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationGlycerolLipidsOzone

Identifiers

PMID34228922
PMCPMC8295983
OpenAlexW3179854668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.