ArticlePLoS computational biology2021
Mechanical feedback and robustness of apical constrictions in Drosophila embryo ventral furrow formation.
Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 12 citations in OpenAlex.
- Single-nucleus multiome ATAC and RNA sequencing reveals the molecular basis of thermal acclimation inbioRxiv : the preprint server for biology · 2025Article
- Studying gastrulation by invagination: The bending of a cell sheet by mechanical cell properties using 3D deformable cell based simulations.PLoS computational biology · 2025Article
- Mechanical control of neural plate folding by apical domain alteration.Nature communications · 2023Article
- The mechanics of cephalic furrow formation in the Drosophila embryo.Biophysical journal · 2023Article
- Mechanical feedback and robustness of apical constrictions in Drosophila embryo ventral furrow formation.PLoS computational biology · 2021Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Formation of the ventral furrow in the Drosophila embryo relies on the apical constriction of cells in the ventral region to produce bending forces that drive tissue invagination. In our recent paper we observed that apical constrictions during the initial phase of ventral furrow formation produce elongated patterns of cellular constriction chains prior to invagination and argued that these are indicative of tensile stress feedback. Here, we quantitatively analyze the constriction patterns preceding ventral furrow formation and find that they are consistent with the predictions of our active-granular-fluid model of a monolayer of mechanically coupled stress-sensitive constricting particles. Our model shows that tensile feedback causes constriction chains to develop along underlying precursor tensile stress chains that gradually strengthen with subsequent cellular constrictions. As seen in both our model and available optogenetic experiments, this mechanism allows constriction chains to penetrate or circumvent zones of reduced cell contractility, thus increasing the robustness of ventral furrow formation to spatial variation of cell contractility by rescuing cellular constrictions in the disrupted regions.
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