Evidence map›Paper›PMID 34228508›Full record

ArticleJCO global oncology2021

Outcomes and Prognostic Factors in a Large Cohort of Hospitalized Cancer Patients With COVID-19.

Guilherme Nader Marta, Renata Colombo Bonadio, Odeli Nicole Encinas Sejas, Gabriel Watarai, Maria Cecilia Mathias Machado, Lorena Teixeira Frasson, Camila Motta Venchiarutti Moniz, Raquel Keiko de Luca Ito, Driele Peixoto, Camilla Oliveira Hoff and 7 more

Open access · goldAbstract read
In one paragraph

Article in JCO global oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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  13. Forging ahead: CANO/ACIO's Strategic Plan for 2022-2024.Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Guilherme Nader MartaMedical Oncology Division, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.ORCID 0000-0001-7864-3637
Renata Colombo BonadioMedical Oncology Division, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.ORCID 0000-0001-5818-922X
Odeli Nicole Encinas SejasInfectious Diseases Division, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.
Gabriel WataraiMedical Oncology Division, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.
Maria Cecilia Mathias MachadoMedical Oncology Division, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.
Lorena Teixeira FrassonMedical Oncology Division, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.
Camila Motta Venchiarutti MonizMedical Oncology Division, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.ORCID 0000-0002-1182-4764
Raquel Keiko de Luca ItoInfectious Diseases Division, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.
Driele PeixotoInfectious Diseases Division, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.ORCID 0000-0001-9454-5236
Camilla Oliveira HoffFaculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.ORCID 0000-0002-4618-8438
Veruska Menegatti AnastacioEmergency Department, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.
Ulysses RibeiroSurgery Department, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.ORCID 0000-0003-1711-7347
Juliana PereiraService of Hematology, Transfusion and Cell Therapy, and Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology (LIM-31), ICESP and Hospital das Clinicas, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.
Vanderson RochaService of Hematology, Transfusion and Cell Therapy, and Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology (LIM-31), ICESP and Hospital das Clinicas, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.
Edson AbdalaInfectious Diseases Division, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.
Maria Del Pilar Estevez-DizMedical Oncology Division, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.
Paulo M HoffMedical Oncology Division, Instituto do Cancer do Estado de São Paulo, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil.ORCID 0000-0002-0065-2194
Instituto do Câncer do Estado de São Paulo · BRUniversidade de São Paulo · BRUniversité Libre de Bruxelles · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePatients with cancer are at increased risk for unfavorable outcomes from COVID-19. Knowledge about the outcome determinants of severe acute respiratory syndrome coronavirus 2 infection in this population is essential for risk stratification and definition of appropriate management. Our objective was to evaluate prognostic factors for all-cause mortality in patients diagnosed with both cancer and COVID-19.

methodsAll consecutive patients with cancer hospitalized at our institution with COVID-19 were included. Electronic medical records were reviewed for clinical and laboratory characteristics potentially associated with outcomes.

resultsFive hundred seventy-six consecutive patients with cancer and COVID-19 were included in the present study. An overall in-hospital mortality rate of 49.3% was demonstrated. Clinical factors associated with increased risk of death because of COVID-19 were age over 65 years, Eastern Cooperative Oncology Group performance status > 0 zero, best supportive care, primary lung cancer, and the presence of lung metastases. Laboratory findings associated with a higher risk of unfavorable outcomes were neutrophilia, lymphopenia, and elevated levels of D-dimer, creatinine, C-reactive protein, or AST.

conclusionA high mortality rate in patients with cancer who were diagnosed with COVID-19 was demonstrated in the present study, emphasizing the need for close surveillance in this group of patients, especially in those with unfavorable prognostic characteristics.

Indexed as

COVID-19NeoplasmsAgedHospitalizationHumansPrognosisSARS-CoV-2

Identifiers

PMID34228508
PMCPMC8457868
OpenAlexW3182150131

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.