Evidence map›Paper›PMID 34228496›Full record

ArticleJournal of bacteriology2021

Leucine-Responsive Regulatory Protein in Acetic Acid Bacteria Is Stable and Functions at a Wide Range of Intracellular pH Levels.

Yuri Ishii, Yuki Shige, Naoki Akasaka, Afi Candra Trinugraha, Haruka Higashikubo, Wakao Fukuda, Shinsuke Fujiwara

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Evidence for ethanol-dependent acetic acid resistance inApplied and environmental microbiology · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuri IshiiDepartment of Bioscience, Graduate School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, Japan.
Yuki ShigeDepartment of Bioscience, Graduate School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, Japan.
Naoki AkasakaDepartment of Bioscience, Graduate School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, Japan.
Afi Candra TrinugrahaDepartment of Bioscience, Graduate School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, Japan.
Haruka HigashikuboDepartment of Bioscience, Graduate School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, Japan.
Wakao FukudaDepartment of Bioscience, Graduate School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, Japan.
Shinsuke FujiwaraDepartment of Bioscience, Graduate School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, Japan.
Kwansei Gakuin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetic acid bacteria grow while producing acetic acid, resulting in acidification of the culture. Limited reports elucidate the effect of changes in intracellular pH on transcriptional factors. In the present study, the intracellular pH of Komagataeibacter europaeus was monitored with a pH-sensitive green fluorescent protein, showing that the intracellular pH decreased from 6.3 to 4.7 accompanied by acetic acid production during cell growth. The leucine-responsive regulatory protein of

Indexed as

Acetic AcidAcetobacteraceaeDNA, BacterialDNA-Binding ProteinsEscherichia coliGene Expression Regulation, BacterialGreen Fluorescent ProteinsHydrogen-Ion ConcentrationLeucine-Responsive Regulatory ProteinProtein BindingAcetic AcidDNA, BacterialDNA-Binding ProteinsGreen Fluorescent ProteinsLeucine-Responsive Regulatory Proteinacetic acid bacteriacytoplasmic acidificationKomagataeibacter europaeusleucine-responsive regulatory proteinpHluorin

Identifiers

PMID34228496
PMCPMC8378475
OpenAlexW3179686635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.