Evidence map›Paper›PMID 34228495›Full record

ArticleInfection and immunity2021

Bile Salts Regulate Zinc Uptake and Capsule Synthesis in a Mastitis-Associated Extraintestinal Pathogenic Escherichia coli Strain.

Michael A Olson, Aleksander Grimsrud, Amanda C Richards, Matthew A Mulvey, Eric Wilson, David L Erickson

Abstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Modulation of TDM-induced granuloma pathology by human lactoferrin: a persistent effect in mice.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Article
  5. Article
  6. Distribution of CRISPR inAnimals : an open access journal from MDPI · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael A OlsonDepartment of Microbiology and Molecular Biology, Brigham Young Universitygrid.253294.b, Provo, Utah, USA.
Aleksander GrimsrudDepartment of Microbiology and Molecular Biology, Brigham Young Universitygrid.253294.b, Provo, Utah, USA.
Amanda C RichardsDivision of Microbiology and Immunology, Pathology Department, University of Utah, Salt Lake City, Utah, USA.
Matthew A MulveyDivision of Microbiology and Immunology, Pathology Department, University of Utah, Salt Lake City, Utah, USA.
Eric WilsonDepartment of Microbiology and Molecular Biology, Brigham Young Universitygrid.253294.b, Provo, Utah, USA.
David L EricksonDepartment of Microbiology and Molecular Biology, Brigham Young Universitygrid.253294.b, Provo, Utah, USA.ORCID 0000-0001-6149-273X

Funding

Training Program in Microbial PathogenesisT32AI055434 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A, PLANELLES, VICENTE · 2004 to 2025
$6.0M
Impact of Flagellin Variants and Receptors on the Progression and Outcome of SepsisR01GM134331 · NIGMS · UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A · 2019 to 2022
$1.6M
Mechanisms of ExPEC Persistence within the GutR21AI135918 · NIAID · UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A · 2018 to 2019
$419k
NIAID NIH HHS R21 AI135918NIAID NIH HHS T32 AI055434NIGMS NIH HHS R01 GM134331
6 · The paper itself

Abstract

Extraintestinal pathogenic Escherichia coli (ExPEC) strains are major causes of urinary and bloodstream infections. ExPEC reservoirs are not completely understood. Some mastitis-associated E. coli (MAEC) strains carry genes associated with ExPEC virulence, including metal scavenging, immune avoidance, and host attachment functions. In this study, we investigated the role of the high-affinity zinc uptake (

Indexed as

AnimalsBacterial CapsulesBile Acids and SaltsEscherichia coli InfectionsEscherichia coli ProteinsExtraintestinal Pathogenic Escherichia coliFemaleMaleMastitisMiceMice, Inbred C57BLSepsisVirulenceVirulence FactorsZincBile Acids and SaltsEscherichia coli ProteinsVirulence FactorsZincbile saltsExPECgroup III capsulemastitis-associated E. colizinc transportZnuABC

Identifiers

PMID34228495
PMCPMC8445175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.