Evidence map›Paper›PMID 34228493›Full record

ArticleMolecular and cellular biology2021

FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair.

Katja Kratz, Mariela Artola-Borán, Saho Kobayashi-Era, Gene Koh, Goncalo Oliveira, Shunsuke Kobayashi, Andreia Oliveira, Xueqing Zou, Julia Richter, Masataka Tsuda and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular and cellular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 24 citations in OpenAlex.

  1. DNA Repair Mechanisms.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Emerging drivers of DNA repeat expansions.Biochemical Society transactions · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. MRE11A: a novel negative regulator of human DNA mismatch repair.Cellular & molecular biology letters · 2024
    Article
  14. Article
  15. Article
  16. FAN1 removes triplet repeat extrusions via a PCNA- and RFC-dependent mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Katja KratzInstitute of Molecular Cancer Research, University of Zurichgrid.7400.3, Zurich, Switzerland.
Mariela Artola-BoránInstitute of Molecular Cancer Research, University of Zurichgrid.7400.3, Zurich, Switzerland.
Saho Kobayashi-EraInstitute of Molecular Cancer Research, University of Zurichgrid.7400.3, Zurich, Switzerland.
Gene KohWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Goncalo OliveiraInstitute of Cancer Research, Department of Medicine I, Comprehensive Cancer Centre, Medical University of Viennagrid.22937.3d, Vienna, Austria.
Shunsuke KobayashiInstitute of Molecular Cancer Research, University of Zurichgrid.7400.3, Zurich, Switzerland.
Andreia OliveiraInstitute of Molecular Cancer Research, University of Zurichgrid.7400.3, Zurich, Switzerland.
Xueqing ZouWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Julia RichterInstitute of Biochemistry of the ETH Zurichgrid.5801.c, Zurich, Switzerland.
Masataka TsudaDepartment of Radiation Genetics, Graduate School of Medicine, Kyoto Universitygrid.258799.8, Kyoto, Japan.
Hiroyuki SasanumaDepartment of Radiation Genetics, Graduate School of Medicine, Kyoto Universitygrid.258799.8, Kyoto, Japan.
Shunichi TakedaDepartment of Radiation Genetics, Graduate School of Medicine, Kyoto Universitygrid.258799.8, Kyoto, Japan.
Joanna I LoizouInstitute of Cancer Research, Department of Medicine I, Comprehensive Cancer Centre, Medical University of Viennagrid.22937.3d, Vienna, Austria.
Alessandro A SartoriInstitute of Molecular Cancer Research, University of Zurichgrid.7400.3, Zurich, Switzerland.
Serena Nik-ZainalAcademic Department of Medical Genetics, The Clinical School, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Josef JiricnyInstitute of Molecular Cancer Research, University of Zurichgrid.7400.3, Zurich, Switzerland.
University of Zurich · CHKyoto University · JPUniversity of Cambridge · GBComprehensive Cancer Center Vienna · ATETH Zurich · CH

Funding

Cancer Research UK 23916Cancer Research UK C60100/A23916Department of Health BRC-12-15-20014
6 · The paper itself

Abstract

Germline mutations in the mismatch repair (MMR) genes

Indexed as

DNA Mismatch RepairAmino Acid SequenceAnimalsAvian ProteinsBase SequenceCell LineChickensEndodeoxyribonucleasesExodeoxyribonucleasesGuanosineHEK293 CellsHumansMethylnitronitrosoguanidineMultifunctional EnzymesMutationThionucleosides6-thioguanosineAvian ProteinsEndodeoxyribonucleasesexodeoxyribonuclease IExodeoxyribonucleasesFAN1 protein, humanGuanosineMethylnitronitrosoguanidineMultifunctional EnzymesThionucleosidesDNA repairEXO1exonucleaseFAN1mismatch repairMLH1MSH6mutational signature

Identifiers

PMID34228493
PMCPMC8384067
OpenAlexW3178735538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.