Evidence map›Paper›PMID 34228343›Full record

ReviewMycopathologia2021

Pulmonary Talaromycosis: A Window into the Immunopathogenesis of an Endemic Mycosis.

Shanti Narayanasamy, John Dougherty, H Rogier van Doorn, Thuy Le

Open access · hybridAbstract readReview
In one paragraph

Review in Mycopathologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. Glutathione Peroxidase fromInternational journal of molecular sciences · 2026
    Article
  2. Recent Advances in the Diagnosis of Talaromycosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
  3. Article
  4. Cardiovascular system characteristics in HIV/AIDS patients with talaromycosis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Talaromycosis from Wuhan: two-case report and literature review.Frontiers in cellular and infection microbiology · 2024
    Review
  15. Article
  16. Article
  17. Impact of pathogen genetics on clinical phenotypes in a population ofbioRxiv : the preprint server for biology · 2023
    Article
  18. Article
  19. Clinical Manifestations of Human Exposure to Fungi.Journal of fungi (Basel, Switzerland) · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Shanti NarayanasamyDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, NC, USA. shanti.narayanasamy@duke.edu.ORCID http://orcid.org/0000-0002-6667-2868
John DoughertyDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, NC, USA.
H Rogier van DoornOxford University Clinical Research Unit, Hanoi, Vietnam.
Thuy LeDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, NC, USA. thuy.le@duke.edu.ORCID http://orcid.org/0000-0002-3393-6580
Duke University · USUniversity of Oxford · GB

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI GEORGIA Doris TOMARAS · 2005 to 2026
$50.5M
Making an early diagnosis of talaromycosis - an approach to reduce morbidity and mortality in advanced HIV disease in Southeast AsiaR01AI143409 · NIAID · DUKE UNIVERSITY · PI LE, THUY · 2019 to 2024
$2.8M
Tropical Medicine Research Center for Talaromycosis in VietnamU01AI169358 · NIAID · DUKE UNIVERSITY · PI Thuy Le · 2022 to 2026
$2.5M
NIAID NIH HHS P30 AI064518NIAID NIH HHS R01 AI143409NIAID NIH HHS U01 AI169358NIH HHS NIH R0101AI143409Wellcome Trust
6 · The paper itself

Abstract

Talaromycosis is an invasive mycosis caused by the thermally dimorphic saprophytic fungus Talaromyces marneffei (Tm) endemic in Asia. Like other endemic mycoses, talaromycosis occurs predominantly in immunocompromised and, to a lesser extent, immunocompetent hosts. The lungs are the primary portal of entry, and pulmonary manifestations provide a window into the immunopathogenesis of talaromycosis. Failure of alveolar macrophages to destroy Tm results in reticuloendothelial system dissemination and multi-organ disease. Primary or secondary immune defects that reduce CD4

Indexed as

HIV InfectionsMycosesTalaromycesHumansLungCavitationEffusionNoduleRespiratory tractTalaromyces marneffeiTalaromycosis

Identifiers

PMID34228343
PMCPMC8536569
OpenAlexW3180910438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.