Evidence map›Paper›PMID 34228259›Full record

ReviewInternational urology and nephrology2022

miRNA biomarkers in renal disease.

Beata Franczyk, Anna Gluba-Brzózka, Robert Olszewski, Magdalena Parolczyk, Magdalena Rysz-Górzyńska, Jacek Rysz

Open access · hybridAbstract readReview
In one paragraph

Review in International urology and nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Beata FranczykDepartment of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Lodz, Poland.
Anna Gluba-BrzózkaDepartment of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Lodz, Poland. aniagluba@yahoo.pl.ORCID http://orcid.org/0000-0003-3322-5655
Robert OlszewskiDepartment of Gerontology, Public Health and Education, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland.
Magdalena ParolczykDepartment of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Lodz, Poland.
Magdalena Rysz-GórzyńskaDepartment of Ophthalmology and Visual Rehabilitation, Medical University of Lodz, Lodz, Poland.
Jacek RyszDepartment of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Lodz, Poland.
Medical University of Lodz · PLInstitute of Fundamental Technological Research · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD), which is characterized by the gradual loss of kidney function, is a growing worldwide problem due to CKD-related morbidity and mortality. There are no reliable and early biomarkers enabling the monitoring, the stratification of CKD progression and the estimation of the risk of CKD-related complications, and therefore, the search for such molecules is still going on. Numerous studies have provided evidence that miRNAs are potentially important particles in the CKD field. Studies indicate that some miRNA levels can be increased in patients with CKD stages III-V and hemodialysis and decreased in renal transplant recipients (miR-143, miR-145 and miR-223) as well as elevated in patients with CKD stages III-V, decreased in hemodialysis patients and even more markedly decreased in renal transplant recipients (miR-126 and miR-155). miRNA have great potential of being sensitive and specific biomarkers in kidney diseases as they are tissue specific and stable in various biological materials. Some promising non-invasive miRNA biomarkers have already been recognized in renal disease with the potential to enhance diagnostic accuracy, predict prognosis and monitor the course of disease. However, large-scale clinical trials enrolling heterogeneous patients are required to evaluate the clinical value of miRNAs.

Indexed as

BiomarkersHumansMicroRNAsRenal Insufficiency, ChronicRisk AssessmentBiomarkersMicroRNAsBiomarkersChronic kidney diseasemiRNA

Identifiers

PMID34228259
PMCPMC8831254
OpenAlexW3181109727

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.