Evidence map›Paper›PMID 34228172›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

Self-reported late effect symptom clusters among young pediatric cancer survivors.

Rebecca Williamson Lewis, Karen E Effinger, Karen Wasilewski-Masker, Ann Mertens, Canhua Xiao

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Associations of Symptom Clusters and Health Outcomes in Adult Survivors of Childhood Cancer: A Report From the St Jude Lifetime Cohort Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rebecca Williamson LewisAflac Cancer and Blood Disorders Center At Children's Healthcare of Atlanta, 2015 Uppergate Dr, 4thFloor, Atlanta, GA, 30322, USA. rebecca.lewis@choa.org.ORCID http://orcid.org/0000-0003-1722-0547
Karen E EffingerAflac Cancer and Blood Disorders Center At Children's Healthcare of Atlanta, 2015 Uppergate Dr, 4thFloor, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0002-9111-9191
Karen Wasilewski-MaskerAflac Cancer and Blood Disorders Center At Children's Healthcare of Atlanta, 2015 Uppergate Dr, 4thFloor, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0002-1261-9594
Ann MertensAflac Cancer and Blood Disorders Center At Children's Healthcare of Atlanta, 2015 Uppergate Dr, 4thFloor, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0003-0989-0962
Canhua XiaoNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-1391-5325

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMost survivors of childhood cancer experience subsequent chronic conditions but little is known about concurrent symptoms. This study seeks to identify late effect symptom clusters among young pediatric cancer survivors.

methodsSurvivors ≥ 18 or parents of survivors < 18 years enrolled in an institutional cohort study indicated (yes/no) if they experienced certain symptoms after treatment. The sample was randomly divided in half for exploratory factor analyses to identify symptom clusters followed by confirmatory factor analyses. Symptoms with ≥ 10% prevalence were included. Cluster structure generalizability across subgroups was examined using congruence coefficients.

resultsThe sample included 579 survivors (74% non-Hispanic white, 45% leukemia, 12.8 ± 4.5 years at survey, 5.9 ± 3.5 years since therapy). Respondents averaged three symptoms. Three clusters were identified: (1) gastrointestinal: abdominal pain, diarrhea, constipation, nausea, vomiting (Cronbach's α = 0.74); (2) psychological: depression, anxiety, memory problems, anger management problems, sleep problems (α = 0.71); and (3) neurologic: problems walking, numbness/tingling, fatigue, back pain, chronic pain, weakness/inability to move legs (α = 0.71). Confirmatory factor analysis confirmed the three-cluster structure (standardized root mean square residual: 0.09; parsimonious goodness of fit: 0.96; Bentler-Bonett normed fit index: 0.95). The gastrointestinal and psychological clusters were generalizable across most subgroups while the neurologic cluster varied across age and race/ethnicity subgroups.

conclusionThree distinct late effect symptom clusters were identified in young childhood cancer survivors with gastrointestinal and psychological clusters remaining relatively stable across subgroups. Future studies should focus on the characteristics of patients who experience these symptoms, especially those with high symptom burden, and the synergistic impact on quality of life.

Indexed as

Cancer SurvivorsNeoplasmsChildCohort StudiesFatigueHumansQuality of LifeSelf ReportSurvivorsSyndromeChildhood cancer survivorLate effectsPediatricSymptoms

Identifiers

PMID34228172

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.