Evidence map›Paper›PMID 34227937›Full record

ArticleeLife2021

Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci.

Victoria J Sugrue, Joseph Alan Zoller, Pritika Narayan, Ake T Lu, Oscar J Ortega-Recalde, Matthew J Grant, C Simon Bawden, Skye R Rudiger, Amin Haghani, Donna M Bond and 8 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Designing Epigenetic Clocks for Wildlife Research.Molecular ecology resources · 2025
    Review
  8. Sex differences in DNA methylation in bats.Annals of the New York Academy of Sciences · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. The androgen clock is an epigenetic predictor of long-term male hormone exposure.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. A life for a (shorter) life: The reproduction-longevity trade-off.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 4 countries.

Victoria J SugrueDepartment of Anatomy, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0002-0427-5146
Joseph Alan ZollerDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, United States.ORCID http://orcid.org/0000-0001-6309-0291
Pritika NarayanApplied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland, Auckland, New Zealand.
Ake T LuDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Oscar J Ortega-RecaldeDepartment of Anatomy, University of Otago, Dunedin, New Zealand.
Matthew J GrantApplied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland, Auckland, New Zealand.
C Simon BawdenLivestock and Farming Systems, South Australian Research and Development Institute, Roseworthy, Australia.
Skye R RudigerLivestock and Farming Systems, South Australian Research and Development Institute, Roseworthy, Australia.
Amin HaghaniDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.ORCID http://orcid.org/0000-0002-6052-8793
Donna M BondDepartment of Anatomy, University of Otago, Dunedin, New Zealand.
Reuben R HoreBlackstone Hill Station, Becks, RD2, Omakau, New Zealand.
Michael GarrattDepartment of Anatomy, University of Otago, Dunedin, New Zealand.
Karen E SearsDepartment of Ecology and Evolutionary Biology, UCLA, Los Angeles, United States.ORCID http://orcid.org/0000-0001-9744-9602
Nan WangCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, United States.
Xiangdong William YangCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, United States.ORCID http://orcid.org/0000-0003-3705-7935
Russell G SnellApplied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland, Auckland, New Zealand.
Timothy A Hore *Department of Anatomy, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0002-6735-225X
Steve Horvath *Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
University of California, Los Angeles · USUniversity of Otago · NZUniversity of Auckland · NZSouth Australian Research and Development Institute · AUBlackstone (United States) · USInstitut de Biologia Evolutiva · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In mammals, females generally live longer than males. Nevertheless, the mechanisms underpinning sex-dependent longevity are currently unclear. Epigenetic clocks are powerful biological biomarkers capable of precisely estimating chronological age and identifying novel factors influencing the aging rate using only DNA methylation data. In this study, we developed the first epigenetic clock for domesticated sheep (

Indexed as

DNA MethylationEpigenesis, GeneticAgingAndrogensAnimalsBiological ClocksFemaleFeminizationMaleOrchiectomySheep, DomesticAndrogensagingandrogenscastrationdevelopmental biologyDNA methylationepigenetic clockgeneticsgenomicshumanmousesheep

Identifiers

PMID34227937
PMCPMC8260231
OpenAlexW3176752981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.