ArticleEpigenetics2022
The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study.
Article in Epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Pooled it
- Employment trajectories and biological aging: Racial and ethnic disparities in work instability and epigenetic age acceleration.SSM - population health · 2026Article
- How education gets under the skin: Pathways linking educational advantage to slower biological aging.Social science & medicine (1982) · 2026Article
- Article
- Article
- Assessing differences in epigenetic aging markers between sexual or gender minority and straight cisgender adults using the Coronary Artery Risk Development in Young Adults cohort.Social science & medicine (1982) · 2026Article
- The contribution of social and economic factors to accelerated biological aging differences between non-Hispanic Black and White adults in the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Epigenetic entropy, socioeconomic differences, and health and lifespan in the Women's Health Initiative.Clinical epigenetics · 2026Article
- Epigenetic g predicts cognitive function in a diverse, nationally representative sample of older adults.Clinical epigenetics · 2026Article
- How "Clocking in" Ages Us: An Examination of Work History, Work Quality, and Accelerated Epigenetic Aging in Older Adulthood.Journal of health and social behavior · 2026Article
- Tracking DNA methylation-based biological age over 8 years and its association with mortality in community-dwelling older adults.Clinical epigenetics · 2026Article
- Biomarkers help us understand how cellular and systemic aging contribute to mortality: a study utilizing a machine-learning approach in the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Epigenetic aging mediates the association between life course socioeconomic status and decrements in kidney function across a decade.GeroScience · 2026Article
- Epigenetic clocks moderate the impact of marital status transitions on health in older adults.PloS one · 2026Article
- Environmental exposures and epigenetic alterations in common chronic diseases: insights and challenges.Environmental epigenetics · 2026Review
- Article
- What's counted counts: the implications of underrepresentation for the application of epigenetic clocks in diverse populations.Clinical epigenetics · 2025Review
- Social determinants of health and biological age among diverse U.S. Adults, NHANES 2011-2018.BMC public health · 2025Article
- Impact of socioeconomic conditions across the life course on epigenetic age acceleration: evidence from a longitudinal cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Remarkable concordance in associations between epigenetic clocks and health behaviors across three countries.Social science & medicine (1982) · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Epigenetic clocks have been widely used to predict disease risk in multiple tissues or cells. Their success as a measure of biological ageing has prompted research on the connection between epigenetic pathways of ageing and the socioeconomic gradient in health and mortality. However, studies examining social correlates of epigenetic ageing have yielded inconsistent results. We conducted a comprehensive, comparative analysis of associations between various dimensions of socioeconomic status (SES) (education, income, wealth, occupation, neighbourhood environment, and childhood SES) and eight epigenetic clocks in two well-powered US ageing studies: The Multi-Ethnic Study of Atherosclerosis (MESA) (n = 1,211) and the Health and Retirement Study (HRS) (n = 4,018). In both studies, we found robust associations between SES measures in adulthood and the GrimAge and DunedinPoAm clocks (Bonferroni-corrected
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.