Evidence map›Paper›PMID 34227840›Full record

ArticleInfection and immunity2021

Role of the Staphylococcus aureus Extracellular Loop of GraS in Resistance to Distinct Human Defense Peptides in PMN and Invasive Cardiovascular infections.

Ambrose L Cheung, Junho Cho, Arnold S Bayer, Michael R Yeaman, Yan Q Xiong, Niles P Donegan, Irina V Mikheyeva, Gi Yong Lee, Soo-Jin Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ambrose L CheungDepartment of Microbiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Junho ChoDepartment of Microbiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Arnold S BayerThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Michael R YeamanThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.ORCID 0000-0002-9468-5252
Yan Q XiongThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Niles P DoneganDepartment of Microbiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0002-8328-2044
Irina V MikheyevaDepartment of Microbiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Gi Yong LeeDepartment of Veterinary Microbiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National Universitygrid.31501.36, Seoul, Republic of Korea.
Soo-Jin YangDepartment of Veterinary Microbiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National Universitygrid.31501.36, Seoul, Republic of Korea.ORCID 0000-0003-3253-8190
Dartmouth College · USUniversity of California, Los Angeles · USSeoul National University · KR

Funding

Systems Immunolobiology of Antibiotic-Persistent MRSA InfectionU01AI124319 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI YEAMAN, MICHAEL R · 2016 to 2020
$10.1M
Staphylococcal Adaptations to Platelet Microbicidal ProteinR01AI039108 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI BAYER, ARNOLD S · 1997 to 2016
$5.1M
The role of GraRS in resistance to cationic antimicrobial peptides in S. aureusR01AI091801 · NIAID · DARTMOUTH COLLEGE · PI CHEUNG, AMBROSE LIN YAU · 2011 to 2015
$2.4M
The role of purine biosynthesis and stringent response in persistent MRSA endovascular infectionsR01AI139244 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI XIONG, YAN Q. · 2019 to 2023
$2.2M
Mitigating Resistance & Virulence in MRSAR33AI111661 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI YEAMAN, MICHAEL R · 2016 to 2018
$1.2M
Mitigating Resistance & Virulence in MRSAR21AI111661 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI YEAMAN, MICHAEL R · 2014 to 2015
$378k
NIAID NIH HHS R01 AI039108NIAID NIH HHS R01 AI091801NIAID NIH HHS R01 AI139244NIAID NIH HHS R21 AI111661NIAID NIH HHS R33 AI111661NIAID NIH HHS U01 AI124319
6 · The paper itself

Abstract

GraS is a membrane sensor in Staphylococcus aureus that induces

Indexed as

AnimalsAntimicrobial Cationic PeptidesBacterial ProteinsCardiovascular InfectionsDrug Resistance, BacterialEndocarditisFemaleGene Expression Regulation, BacterialHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMicrobial ViabilityNeutrophilsRabbitsStaphylococcal InfectionsAntimicrobial Cationic PeptidesBacterial Proteinscardiovascular infectionscationic host defense peptides (HDPs)GraRSGraS membrane sensorHA-MRSApH responseStaphylococcus aureustwo-component regulatory system (TCRS)

Identifiers

PMID34227840
PMCPMC8445198
OpenAlexW3182312717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.