Evidence map›Paper›PMID 34227838›Full record

ArticleInfection and immunity2021

Gastrointestinal Chlamydia-Induced CD8

Qi Tian, Zengzi Zhou, Luying Wang, Xin Sun, Bernard Arulanandam, Dabao Xu, Min Xue, Guangming Zhong

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Impact of oralmSystems · 2025
    Article
  5. Infectivity of a pathogenicity-attenuatedInfection and immunity · 2025
    Article
  6. Insights into intestinal barrier disruption during long-term gutFrontiers in cellular and infection microbiology · 2025
    Article
  7. Diverse animal models forFrontiers in microbiology · 2024
    Review
  8. Review
  9. Article
  10. Characterization of Pathogenic CD8Infection and immunity · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Qi TianDepartment of Medical Genetics, Maternal and Child Health Hospital of Hunan Province, Changsha, Hunan, China.
Zengzi ZhouThe 3rd Xiangya Hospital, Central South Universitygrid.216417.7, Changsha, Hunan, China.
Luying WangThe 3rd Xiangya Hospital, Central South Universitygrid.216417.7, Changsha, Hunan, China.
Xin SunThe 3rd Xiangya Hospital, Central South Universitygrid.216417.7, Changsha, Hunan, China.
Bernard ArulanandamDepartment of Biology, The University of Texas at San Antoniogrid.215352.2, San Antonio, Texas, USA.
Dabao XuThe 3rd Xiangya Hospital, Central South Universitygrid.216417.7, Changsha, Hunan, China.
Min XueThe 3rd Xiangya Hospital, Central South Universitygrid.216417.7, Changsha, Hunan, China.
Guangming ZhongDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.ORCID 0000-0001-7053-5009
Central South University · CNThe University of Texas at San Antonio · USThe University of Texas Health Science Center at San Antonio · US

Funding

MECHANISMS OF CHLAMYDIAL EVASION OF IMMUNE RECOGNATIONR01AI047997 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2000 to 2021
$6.9M
Chlamydial plasmid-dependent pathogenesisR01AI121989 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2016 to 2019
$1.9M
Genital Chlamydia spreading to the gastrointestinal tract promotes chlamydial pathogenicity in the upper genital tractR21AI151724 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2020 to 2021
$416k
NIAID NIH HHS R01 AI047997NIAID NIH HHS R01 AI121989NIAID NIH HHS R21 AI151724
6 · The paper itself

Abstract

Chlamydia is known to both ascend to the upper genital tract and spread to the gastrointestinal tract following intravaginal inoculation. Gastrointestinal Chlamydia was recently reported to promote chlamydial pathogenicity in the genital tract since mice intravaginally inoculated with an attenuated Chlamydia strain, which alone failed to develop pathology in the genital tract, were restored to develop hydrosalpinx by intragastric coinoculation with wild-type Chlamydia. Gastrointestinal Chlamydia promoted hydrosalpinx via an indirect mechanism since Chlamydia in the gut did not directly spread to the genital tract lumen. In the current study, we further investigated the role of CD8

Indexed as

Adoptive TransferAnimalsCD8-Positive T-LymphocytesCell Line, TumorChlamydiaChlamydia InfectionsDisease Models, AnimalFemaleGastrointestinal TractGenitalia, FemaleHeLa CellsHumansMiceMice, Inbred CBAReproductive Tract InfectionsCD8+ T cellschlamydial spreadinggut Chlamydiahydrosalpinxtwo-hit hypothesis

Identifiers

PMID34227838
PMCPMC8445165
OpenAlexW3181899211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.