Evidence map›Paper›PMID 34227740›Full record

ArticleJournal of cellular and molecular medicine2021

Alginate oligosaccharide alleviates D-galactose-induced cardiac ageing via regulating myocardial mitochondria function and integrity in mice.

Wenjing Feng, Jianya Liu, Shan Wang, Yi Hu, Hui Pan, Ting Hu, Huashi Guan, Dongfeng Zhang, Yongjun Mao

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Role of gallic acid in sarcopenia in D-galactose-treated mice.Iranian journal of basic medical sciences · 2026
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  14. International journal of nanomedicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Wenjing FengDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
Jianya LiuDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
Shan WangDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
Yi HuDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
Hui PanDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
Ting HuKey Laboratory of Marine Drugs, Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Huashi GuanKey Laboratory of Marine Drugs, Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Dongfeng ZhangDepartment of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, Qingdao, China.
Yongjun MaoDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.ORCID 0000-0001-7000-614X
Qingdao University · CNMarine Biomedical Research Institute of Qingdao · CNQingdao National Laboratory for Marine Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ageing is a crucial risk factor for the development of age-related cardiovascular diseases. Therefore, the molecular mechanisms of ageing and novel anti-ageing interventions need to be deeply studied. Alginate oligosaccharide (AOS) possesses high pharmacological activities and beneficial effects. Our study was undertaken to investigate whether AOS could be used as an anti-ageing drug to alleviate cardiac ageing. D-galactose (D-gal)-induced C57BL/6J ageing mice were established by subcutaneous injection of D-gal (200 mg·kg

Indexed as

AgingAlginatesAnimalsAntioxidantsGalactoseMaleMiceMice, Inbred C57BLMitochondria, HeartMitochondrial TurnoverMyocytes, CardiacNatriuretic PeptidesOxidative StressReactive Oxygen SpeciesAlginatesAntioxidantsGalactoseNatriuretic PeptidesReactive Oxygen Speciesalginate oligosaccharidecardiac ageingD-galactosemitochondriaoxidative stress

Identifiers

PMID34227740
PMCPMC8335675
OpenAlexW3181653921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.