Evidence map›Paper›PMID 34227631›Full record

ReviewChemical Society reviews2021

Biosensing with DNAzymes.

Erin M McConnell, Ioana Cozma, Quanbing Mou, John D Brennan, Yi Lu, Yingfu Li

Abstract readReview
In one paragraph

Review in Chemical Society reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Dual-functional nanoplatform for simultaneous degradation of circRNAJournal of Zhejiang University. Science. B · 2026
    Article
  6. Article
  7. Light-Inducible Bispecific DNAzymes Reveal Mitochondrial FeAngewandte Chemie (International ed. in English) · 2026
    Article
  8. Article
  9. Mechanozyme: An Artificial Enzyme With a Mechanophore Framework.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Article
  11. Article
  12. Biosensing With Nanofluidics.Exploration (Beijing, China) · 2026
    Review
  13. Article
  14. Review
  15. Review
  16. Simultaneous Imaging of CuAngewandte Chemie (International ed. in English) · 2026
    Article
  17. Article
  18. Review
  19. Review
  20. Review

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erin M McConnellDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada. liying@mcmaster.ca.
Ioana Cozma
Quanbing Mou
John D Brennan
Yi Lu
Yingfu Li

Funding

Design and Selection of Novel Metalloenzymes for Biocatalysis, Bioimaging, and Genetic EngineeringR35GM141931 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Yi Lu · 2021 to 2026
$3.5M
Selection and Sensing Applications of DNAzymes Selective for Paramagnetic Metal IonsR01GM124316 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI LU, YI · 2017 to 2020
$1.4M
Novel DNAzyme sensors for lithium and sodium to understand cellular and molecular mechanisms of lithium treatment of bipolar disorderR21MH110975 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LU, YI · 2016 to 2017
$401k
NIGMS NIH HHS R01 GM124316NIGMS NIH HHS R35 GM141931NIMH NIH HHS R21 MH110975
6 · The paper itself

Abstract

This article provides a comprehensive review of biosensing with DNAzymes, providing an overview of different sensing applications while highlighting major progress and seminal contributions to the field of portable biosensor devices and point-of-care diagnostics. Specifically, the field of functional nucleic acids is introduced, with a specific focus on DNAzymes. The incorporation of DNAzymes into bioassays is then described, followed by a detailed overview of recent advances in the development of in vivo sensing platforms and portable sensors incorporating DNAzymes for molecular recognition. Finally, a critical perspective on the field, and a summary of where DNAzyme-based devices may make the biggest impact are provided.

Indexed as

Biosensing TechniquesAnimalsDNA, CatalyticHumansDNA, Catalytic

Identifiers

PMID34227631
PMCPMC9136875

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.