Evidence map›Paper›PMID 34227370›Full record

ArticleSe pu = Chinese journal of chromatography2021

[Efficient screening for 8-oxoguanine DNA glycosylase binding aptamers via capillary electrophoresis].

Shimiao Han, Liping Zhao, Ge Yang, Feng Qu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Se pu = Chinese journal of chromatography, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. [Annual review of capillary electrophoresis technology in 2021].Se pu = Chinese journal of chromatography · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shimiao HanSchool of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Liping ZhaoSchool of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Ge YangSchool of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Feng QuSchool of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Beijing Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

8-Oxoguanine DNA glycosylase (OGG1) is an important enzyme that plays a key role in oxidative DNA damage repair. OGG1 can specifically recognize and excise 8-oxoG (a product of oxidative damage found in double-stranded DNA) through base excision repair (BER). OGG1 is expressed in normal tissues, and in most tumor tissues. Oxidative cellular damage can produce an inflammatory reaction, alleviating some measure of constitutive OGG1 inhibition. OGG1 inhibition in cancer cells shows some promise as a new method of cancer treatment. Most current OGG1 research focuses on regulating OGG1 with targeted small molecules. To date, no aptamer screen for OGG1 has been reported. Aptamers are single-stranded DNA (ssDNA) or RNA oligonucleotides that can bind to a target with high affinity and specificity

Indexed as

Aptamers, NucleotideDNA GlycosylasesDNA, Single-StrandedElectrophoresis, CapillaryGuanineMolecular Docking SimulationSELEX Aptamer Technique8-hydroxyguanineAptamers, NucleotideDNA GlycosylasesDNA, Single-StrandedGuanine8-oxoguanine DNA glycosylaseaptamercapillary electrophoresis (CE)multi-round selectionone-round pressure controllable selection

Identifiers

PMID34227370
PMCPMC9404054
OpenAlexW3179155304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.