Evidence map›Paper›PMID 34227244›Full record

ArticleBrain and behavior2021

QKI 6 ameliorates CIRI through promoting synthesis of triglyceride in neuron and inhibiting neuronal apoptosis associated with SIRT1-PPARγ-PGC-1α axis.

Rui Liu, Hongzeng Li, Jingyuan Deng, Qunqiang Wu, Chunhua Liao, Qun Xiao, Qi Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. The sirtuin family in health and disease.Signal transduction and targeted therapy · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rui LiuDepartment of Rehabilitation, Tangdu Hospital, Fourth Military Medical University, Xi'an, PR China.
Hongzeng LiDepartment of Gerontology, Tangdu Hospital, Fourth Military Medical University, Xi'an, PR China.
Jingyuan DengDepartment of Encephalology, the First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, PR China.
Qunqiang WuDepartment of Rehabilitation, Tangdu Hospital, Fourth Military Medical University, Xi'an, PR China.
Chunhua LiaoDepartment of Rehabilitation, Tangdu Hospital, Fourth Military Medical University, Xi'an, PR China.
Qun XiaoDepartment of Rehabilitation, Tangdu Hospital, Fourth Military Medical University, Xi'an, PR China.
Qi ChangDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, PR China.ORCID 0000-0001-7985-580X
Tang Du Hospital · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNPeople's Liberation Army No. 150 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe stroke induced by ischemia of brain remains high incidence and death rate. The study wanted to confirm the effects of Quaking 6 (QKI 6) on the protection role in neurons of rat model of cerebral ischemia/reperfusion injury (CIRI). MATERIAL AND

methodsThe rat model with CIRI induced by middle cerebral artery occlusion was well established and rat neurons were isolated to characterize the effects of QKI 6 mediated by sirtuin 1 (SIRT1) on synthesis of triglyceride in neuron and neuronal apoptosis via activation of SIRT1-peroxisome proliferater-activated receptor (PPAR)γ- peroxisome proliferator-activated receptor coactivator (PGC)-1α signaling pathway.

resultsThe expression levels of SIRT1 or QKI 6, and acetylation level of QKI 6 were decreased in neurons of rat model with CIRI. QKI 6 deacetylated and mediated by SIRT1 that contributed to suppressing the progression of neuronal apoptosis in rat through promoting synthesis of triglyceride in vivo and in vitro via SIRT1-PPARγ-PGC-1α signaling pathway, then inhibiting CIRI.

conclusionsOur results demonstrated SIRT1 deacetylates QKI 6, the RNA-binding protein, that affects significantly the synthesis of triglyceride in neurons of CIRI rat model. Moreover, it activated transcription factor peroxisome proliferator-activated receptorγ coactivator-1α (PGC-1α) through post-transcriptional regulation of the expression of PPARγ, and further enhanced synthesis of triglyceride, thereby restrained the progression of neural apoptosis and CIRI.

Indexed as

Reperfusion InjurySirtuin 1AnimalsApoptosisNeuronsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPAR gammaRatsRNA-Binding ProteinsTriglyceridesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPAR gammaPpargc1a protein, ratQk protein, ratRNA-Binding ProteinsSirt1 protein, ratSirtuin 1Triglyceridescerebral ischemia/reperfusion injurymiddle cerebral artery occlusionneuronal apoptosisQuaking 6sirtuin 1synthesis of triglyceride

Identifiers

PMID34227244
PMCPMC8413718
OpenAlexW3182801409

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.