Evidence map›Paper›PMID 34227101›Full record

ArticleThe British journal of dermatology2022

The epidemiology of alopecia areata: a population-based cohort study in UK primary care.

M Harries, A E Macbeth, S Holmes, W S Chiu, W R Gallardo, M Nijher, S de Lusignan, C Tziotzios, A G Messenger

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in The British journal of dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 4 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

M HarriesThe Dermatology Centre, Salford Royal NHS Foundation Trust, Salford, Greater Manchester, M6 8HD UK; Centre for Dermatology Research, University of Manchester, MAHSC and NIHR Manchester Biomedical Research Centre, Manchester, M13 9PL, UK.ORCID 0000-0002-0563-8690
A E MacbethDepartment of Dermatology, Norfolk & Norwich University Hospitals NHS Foundation Trust, Norwich, NR4 7UY, UK.
S HolmesAlan Lyell Centre for Dermatology, Queen Elizabeth University Hospital, Glasgow, G51 4TF, UK.
W S ChiuPfizer Ltd, Walton Oaks, Walton on the Hill, Tadworth, Surrey, KT20 7NS, UK.
W R GallardoPfizer Ltd, Walton Oaks, Walton on the Hill, Tadworth, Surrey, KT20 7NS, UK.
M NijherPfizer Ltd, Walton Oaks, Walton on the Hill, Tadworth, Surrey, KT20 7NS, UK.
S de LusignanDepartment of Primary Care Health Sciences, University of Oxford, OX2 6GG, UK; Oxford-Royal College of General Practitioners, Research and Surveillance Centre, London, NW1 2FB, UK.ORCID 0000-0002-8553-2641
C TziotziosSt John's Institute of Dermatology, Guy's and St Thomas' Hospitals & King's College London, London, SE1 9RT, UK.ORCID 0000-0003-1662-4494
A G MessengerDepartment of Dermatology, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK.ORCID 0000-0003-1424-8069
Pfizer (United Kingdom) · GBManchester Academic Health Science Centre · GBNorfolk and Norwich University Hospitals NHS Foundation Trust · GBQueen Elizabeth University Hospital · GBRoyal Hallamshire Hospital · GBSt Thomas' Hospital · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a lack of population-based information on the disease burden and management of alopecia areata (AA).

objectivesTo describe the epidemiology of AA, focusing on incidence, demographics and patterns of healthcare utilization.

methodsPopulation-based cohort study of 4·16 million adults and children, using UK electronic primary care records from the Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) network database, 2009-2018. The incidence and point prevalence of AA were estimated. Variation in AA incidence by age, sex, deprivation, geographical distribution and ethnicity was examined. Patterns of healthcare utilization were evaluated in people with incident AA.

resultsThe AA incidence rate was 0·26 per 1000 person-years. AA point prevalence in 2018 was 0·58% in adults. AA onset peaked at age 25-29 years for both sexes, although the peak was broader in females. People of nonwhite ethnicity were more likely to present with AA, especially those of Asian ethnicity [incidence rate ratio (IRR) 3·32 (95% confidence interval 3·11-3·55)]. Higher AA incidence was associated with social deprivation [IRR most vs. least deprived quintile 1·47 (1·37-1·59)] and urban living [IRR 1·23 (1·14-1·32)]. People of higher social deprivation were less likely to be referred for specialist dermatology review.

conclusionsBy providing the first large-scale estimates of the incidence and point prevalence of AA, our study helps to understand the burden of AA on the population. Understanding the variation in AA onset between different population groups may give insight into the pathogenesis of AA and its management.

Indexed as

Alopecia AreataAdultChildCohort StudiesFemaleHumansIncidenceMalePrimary Health CareUnited Kingdom

Identifiers

PMID34227101
PMCPMC9298423
OpenAlexW3179331955

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.