Evidence map›Paper›PMID 34227023›Full record

ReviewCurrent neurology and neuroscience reports2021

A Lifecourse Perspective on Female Sex-Specific Risk Factors for Later Life Cognition.

Amalia Peterson, Sarah E Tom

Abstract readReview
In one paragraph

Review in Current neurology and neuroscience reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Geriatric syndromes in women living with HIV.Current opinion in HIV and AIDS · 2026
    Review
  2. Article
  3. Article
  4. Number of children and risk of dementia: a cohort study.Journal of epidemiology and community health · 2025
    Article
  5. Article
  6. Higher Number of Children Is Associated With Increased Risk of Generalization Deficits in Older African American Women.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
    Article
  7. Article
  8. Connections between reproductive health and cognitive aging among women enrolled in the HCHS/SOL and SOL-INCA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Fertility History and Risk of Cognitive Impairment Among Older Parents in the United States.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Amalia PetersonDepartment of Neurology, College of Physicians and Surgeons, Columbia University, 622 W. 168th Street, New York, NY, 10032, USA. ajp2260@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-7015-7957
Sarah E TomDepartment of Neurology, College of Physicians and Surgeons, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.

Funding

NEUROEPIDEMIOLOGY TRAINING PROGRAMT32NS007153 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GU, YIAN, WILLEY, JOSHUA ZEBADIAH · 1987 to 2023
$6.2M
NINDS NIH HHS T32 NS007153
6 · The paper itself

Abstract

purpose of reviewThe prevalence of Alzheimer's disease and related dementias is greater in women compared to men. We provide a review of female sex-specific risk factors across the lifecourse for cognition in older adulthood, highlighting areas that need further study. RECENT

findingsPregnancy may affect late-life cognition, with adverse pregnancy outcomes associated with an increased risk of cognitive decline but parity providing a protective effect. Cumulative estrogen exposure, influenced by age of menarche, menopause, and exogenous estrogen use, may modify a woman's risk for dementia. Menopause transition-associated symptoms may impact cognitive health at the time of the symptoms, but long-term effects remain unknown. As compared to natural menopause, surgical menopause seems to increase the risk for cognitive impairment. Studies that have assessed the association between women's reproductive health and cognition have produced conflicting results. Future studies that address these inconsistencies among diverse populations are needed to better care for women throughout their lives.

Indexed as

Cognitive DysfunctionMenopauseAgedCognitionEstrogensFemaleHumansMalePregnancyRisk FactorsEstrogensAlzheimer’s diseaseDementiaReproductive healthRisk factorsSexWomen

Identifiers

PMID34227023
PMCPMC8449307

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.