Evidence map›Paper›PMID 34226971›Full record

ArticleVirchows Archiv : an international journal of pathology2022

Transdifferentiation of mantle cell lymphoma into sarcoma with limited neuromuscular differentiation after conventional chemotherapy.

Ichiro Kawashima, Naoki Oishi, Kazunari Kasai, Tomohiro Inoue, Eriko Hosokawa, Ayato Nakadate, Minori Matsuura, Takuma Kumagai, Megumi Koshiishi, Takeo Yamamoto and 4 more

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ichiro KawashimaDepartment of Hematology and Oncology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.ORCID http://orcid.org/0000-0002-2242-1266
Naoki OishiDepartment of Pathology, University of Yamanashi, Chuo, Yamanashi, Japan.ORCID http://orcid.org/0000-0002-9365-1093
Kazunari KasaiDepartment of Pathology, University of Yamanashi, Chuo, Yamanashi, Japan.
Tomohiro InoueDepartment of Pathology, University of Yamanashi, Chuo, Yamanashi, Japan.
Eriko HosokawaDepartment of Hematology and Oncology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Ayato NakadateDepartment of Hematology and Oncology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Minori MatsuuraDepartment of Hematology and Oncology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Takuma KumagaiDepartment of Hematology and Oncology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Megumi KoshiishiDepartment of Hematology and Oncology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Takeo YamamotoDepartment of Hematology and Oncology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Kei NakajimaDepartment of Hematology and Oncology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Masaru TanakaDepartment of Hematology and Oncology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Tetsuo KondoDepartment of Pathology, University of Yamanashi, Chuo, Yamanashi, Japan.ORCID http://orcid.org/0000-0003-2268-0302
Keita KiritoDepartment of Hematology and Oncology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan. kirito@yamanashi.ac.jp.ORCID http://orcid.org/0000-0001-5682-2132
University of Yamanashi Hospital · JPUniversity of Yamanashi · JP

Funding

Japan Society for the Promotion of Science 19K16554
6 · The paper itself

Abstract

We report an exceptionally rare case of mantle cell lymphoma (MCL) that transdifferentiated into sarcoma with limited neuromuscular differentiation. An 81-year-old man with t(11;14)-positive MCL was treated with rituximab and bendamustine and achieved complete remission; however, just 2 months later, the patient developed multiple systemic tumors. Pathologic studies revealed round cell sarcoma expressing synaptophysin, CD56, and myogenin without any B-cell markers. The CCND1 translocation and an identical IGL gene rearrangement were shared by both the MCL and sarcoma. Whole-exome sequencing detected 189 single nucleotide variants (SNVs) in the MCL and 205 SNVs in the sarcoma; 160 SNVs including NSD2, ATM, RB1, and TP53 mutations were shared between MCL and sarcoma cells. An additional PTPN11 mutation was specifically found in the sarcoma. These findings confirmed the shared clonal origin of MCL and sarcoma in this patient and indicated that MCL can transdifferentiate into sarcoma in rare cases.

Indexed as

Lymphoma, Mantle-CellSarcomaSoft Tissue NeoplasmsAged, 80 and overCell TransdifferentiationGenes, ImmunoglobulinHumansMaleMutationATMCCND1Mantle cell lymphomaSarcomaTP53Transdifferentiation

Identifiers

PMID34226971
OpenAlexW3181830639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.