Evidence map›Paper›PMID 34226849›Full record

ArticleObesity science & practice2021

Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID-19.

Sérgio Brasil, Alessandra Covallero Renck, Fabio Silvio Taccone, Davi Jorge Fontoura Solla, Bruno Martins Tomazini, Sâmia Yasin Wayhs, Sérgio Fonseca, Estevão Bassi, Bruno Lucena, Ricardo De Carvalho Nogueira and 4 more

Open access · goldAbstract read
In one paragraph

Article in Obesity science & practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Sérgio BrasilUniversidade de São Paulo Brazil.ORCID https://orcid.org/0000-0003-2397-9947
Alessandra Covallero RenckUniversidade de São Paulo Brazil.
Fabio Silvio TacconeUniversitè Libre de Bruxelles Belgium.
Davi Jorge Fontoura SollaUniversidade de São Paulo Brazil.
Bruno Martins TomaziniUniversidade de São Paulo Brazil.
Sâmia Yasin WayhsUniversidade de São Paulo Brazil.
Sérgio FonsecaUniversidade de São Paulo Brazil.
Estevão BassiUniversidade de São Paulo Brazil.
Bruno LucenaUniversidade de São Paulo Brazil.
Ricardo De Carvalho NogueiraUniversidade de São Paulo Brazil.
Wellingson PaivaUniversidade de São Paulo Brazil.
Manoel Jacobsen TeixeiraUniversidade de São Paulo Brazil.
Elaine Maria Frade CostaUniversidade de São Paulo Brazil.
Luiz Marcelo Sá MalbouissonUniversidade de São Paulo Brazil.
Universidade de São Paulo · BRUniversité Libre de Bruxelles · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Multiple factors have been identified as causes of intracranial compliance impairment (ICCI) among patients with obesity. On the other hand, obesity has been linked with worst outcomes in COVID-19. Thus, the hypothesis of severe acute respiratory syndrome (SARS) conducing to cerebral hemodynamic disorders (CHD) able to worsen ICCI and play an additional role on prognosis determination for COVID-19 among obese patients becomes suitable. Methods: 50 cases of SARS by COVID-19 were evaluated, for the presence of ICCI and cerebrovascular circulatory disturbances in correspondence with whether unfavorable outcomes (death or impossibility for mechanical ventilation weaning [MVW]) within 7 days after evaluation. The objective was to observe whether obese patients (BMI ≥ 30) disclosed worse outcomes and tests results compared with lean subjects with same clinical background. Results: 23 (46%) patients among 50 had obesity. ICCI was verified in 18 (78%) obese, whereas in 13 (48%) of 27 non-obese ( Conclusion: In the present study, intracranial compliance impairment was significantly more observed among obese subjects and may have contributed for SARS COVID-19 worsen prognosis.

Indexed as

cerebral hemodynamicsCOVID‐19intracranial complianceobesitysevere acute respiratory syndrome

Identifiers

PMID34226849
PMCPMC8242615
OpenAlexW3165113293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.