Evidence map›Paper›PMID 34226608›Full record

ArticleScientific reports2021

Zfp57 inactivation illustrates the role of ICR methylation in imprinted gene expression during neural differentiation of mouse ESCs.

Basilia Acurzio, Ankit Verma, Alessia Polito, Carlo Giaccari, Francesco Cecere, Salvatore Fioriniello, Floriana Della Ragione, Annalisa Fico, Flavia Cerrato, Claudia Angelini and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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  6. ICF1-Syndrome-AssociatedBiomolecules · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Basilia Acurzio *Department of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli", 81100, Caserta, Italy.
Ankit Verma *Department of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli", 81100, Caserta, Italy.
Alessia PolitoInstitute of Genetics and Biophysics (IGB), Adriano Buzzati-Traverso", Consiglio Nazionale delle Ricerche (CNR), 80131, Naples, Italy.
Carlo GiaccariDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli", 81100, Caserta, Italy.
Francesco CecereDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli", 81100, Caserta, Italy.
Salvatore FiorinielloInstitute of Genetics and Biophysics (IGB), Adriano Buzzati-Traverso", Consiglio Nazionale delle Ricerche (CNR), 80131, Naples, Italy.
Floriana Della RagioneInstitute of Genetics and Biophysics (IGB), Adriano Buzzati-Traverso", Consiglio Nazionale delle Ricerche (CNR), 80131, Naples, Italy.
Annalisa FicoInstitute of Genetics and Biophysics (IGB), Adriano Buzzati-Traverso", Consiglio Nazionale delle Ricerche (CNR), 80131, Naples, Italy.
Flavia CerratoDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli", 81100, Caserta, Italy.
Claudia AngeliniInstitute for Applied Mathematics (IAC) "Mauro Picone", Consiglio Nazionale delle Ricerche (CNR), 80131, Naples, Italy.
Robert FeilInstitute of Molecular Genetics of Montpellier (IGMM), Centre National de Recherche Scientifique (CNRS), 34293, Montpellier, France.
Andrea RiccioDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli", 81100, Caserta, Italy. andrea.riccio@unicampania.it.
Institute of Genetics and Biophysics · ITUniversity of Campania "Luigi Vanvitelli" · ITInstitut de Génétique Moléculaire de Montpellier · FRNational Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ZFP57 is required to maintain the germline-marked differential methylation at imprinting control regions (ICRs) in mouse embryonic stem cells (ESCs). Although DNA methylation has a key role in genomic imprinting, several imprinted genes are controlled by different mechanisms, and a comprehensive study of the relationship between DMR methylation and imprinted gene expression is lacking. To address the latter issue, we differentiated wild-type and Zfp57

Indexed as

AnimalsCell DifferentiationChromosomesDNA MethylationGene Expression Regulation, DevelopmentalGenomic ImprintingMiceMouse Embryonic Stem CellsNeural Stem CellsRepressor ProteinsRepressor ProteinsZfp-57 protein, mouse

Identifiers

PMID34226608
PMCPMC8257706
OpenAlexW3179031768

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.