Evidence map›Paper›PMID 34226579›Full record

ArticleScientific reports2021

The evaluation of zebrafish cardiovascular and behavioral functions through microfluidics.

Satishkumar Subendran, Yi-Chieh Wang, Yueh-Hsun Lu, Chia-Yuan Chen

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
  5. Article
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  7. Article
  8. Review
  9. Pharmaceutical biology · 2022
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Satishkumar SubendranDepartment of Mechanical Engineering, National Cheng Kung University, No. 1 University Road, Tainan, 701, Taiwan.
Yi-Chieh WangDepartment of Mechanical Engineering, National Cheng Kung University, No. 1 University Road, Tainan, 701, Taiwan.
Yueh-Hsun LuDepartment of Radiology, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, 235, Taiwan.
Chia-Yuan ChenDepartment of Mechanical Engineering, National Cheng Kung University, No. 1 University Road, Tainan, 701, Taiwan. chiayuac@mail.ncku.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study proposed a new experimental approach for the vascular and phenotype evaluation of the non-anesthetized zebrafish with representative imaging orientations for heart, pectoral fin beating, and vasculature views by means of the designed microfluidic device through inducing the optomotor response and hydrodynamic pressure control. In order to provide the visual cues for better positioning of zebrafish, computer-animated moving grids were generated by an in-house control interface which was powered by the larval optomotor response, in conjunction with the pressure suction control. The presented platform provided a comprehensive evaluation of internal circulation and the linked external behaviors of zebrafish in response to the cardiovascular parameter changes. The insights from these imaging sections was extended to identify the linkage between the cardiac parameters and behavioral endpoints. In addition, selected chemicals such as ethanol and caffeine were employed for the treatment of zebrafish. The obtained findings can be applicable for future investigation in behavioral drug screening serving as the forefront in psychopharmacological and cognition research.

Indexed as

AnimalsBehavior, AnimalCardiovascular Physiological PhenomenaCardiovascular SystemLarvaMicrofluidicsSwimmingZebrafish

Identifiers

PMID34226579
PMCPMC8257654

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.