Evidence map›Paper›PMID 34226548›Full record

ArticleNature communications2021

4D polycarbonates via stereolithography as scaffolds for soft tissue repair.

Andrew C Weems, Maria C Arno, Wei Yu, Robert T R Huckstepp, Andrew P Dove

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Immunomodulatory Delivery Materials for Tissue Repair.Advanced healthcare materials · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Digital Light Processing to Afford High Resolution and Degradable COAngewandte Chemie (International ed. in English) · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew C WeemsSchool of Chemistry, University of Birmingham, Birmingham, UK. weemsac@ohio.edu.
Maria C ArnoSchool of Chemistry, University of Birmingham, Birmingham, UK.ORCID 0000-0003-1734-4777
Wei YuSchool of Chemistry, University of Birmingham, Birmingham, UK.
Robert T R HucksteppSchool of Life Sciences, University of Warwick, Coventry, UK.ORCID 0000-0003-4410-3397
Andrew P DoveSchool of Chemistry, University of Birmingham, Birmingham, UK. a.dove@bham.ac.uk.ORCID 0000-0001-8208-9309

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3D printing has emerged as one of the most promising tools to overcome the processing and morphological limitations of traditional tissue engineering scaffold design. However, there is a need for improved minimally invasive, void-filling materials to provide mechanical support, biocompatibility, and surface erosion characteristics to ensure consistent tissue support during the healing process. Herein, soft, elastomeric aliphatic polycarbonate-based materials were designed to undergo photopolymerization into supportive soft tissue engineering scaffolds. The 4D nature of the printed scaffolds is manifested in their shape memory properties, which allows them to fill model soft tissue voids without deforming the surrounding material. In vivo, adipocyte lobules were found to infiltrate the surface-eroding scaffold within 2 months, and neovascularization was observed over the same time. Notably, reduced collagen capsule thickness indicates that these scaffolds are highly promising for adipose tissue engineering and repair.

Indexed as

ElasticityAdipose TissueAnimalsCells, CulturedMalePolycarboxylate CementPolymersPorosityPrinting, Three-DimensionalRatsStereolithographyTissue EngineeringTissue ScaffoldspolycarbonatePolycarboxylate CementPolymers

Identifiers

PMID34226548
PMCPMC8257657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.