ArticleNature communications2021
The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Distinct roles of the JADE and BRPF scaffolding subunits of the acetyltransferase HBO1 complex.Nature communications · 2026Article
- PICALM::MLLT10 translocated leukemia.FEBS letters · 2026Review
- Mechanistic insights into histone recognition and H3K14 acetylation by the NuA3 histone acetyltransferase complex.Nature communications · 2025Article
- Pathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes.American journal of human genetics · 2024Article
- Guiding the HBO1 complex function through the JADE subunit.Nature structural & molecular biology · 2024Article
- Histone H4K16ac Binding Function of the Triple PHD Finger Cassette of MLL4.Journal of molecular biology · 2024Article
- Signature construction and molecular subtype identification based on liver-specific genes for prediction of prognosis, immune activity, and anti-cancer drug sensitivity in hepatocellular carcinoma.Cancer cell international · 2024Article
- Non-histone binding functions of PHD fingers.Trends in biochemical sciences · 2023Review
- KDM4 Demethylases: Structure, Function, and Inhibitors.Advances in experimental medicine and biology · 2023Article
- Histone Readers and Their Roles in Cancer.Cancer treatment and research · 2023Article
- CXCR4 Mediates Enhanced Cell Migration inFrontiers in oncology · 2021Article
- Genetic Characterization of Pediatric Mixed Phenotype Acute Leukemia (MPAL).Cancer genomics & proteomicsArticle
- Acute Undifferentiated Leukemia With a Balanced t(5;10)(q35;p12) Resulting in Fusion ofCancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Brianna J Klein *Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
Anagha Deshpande *Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Khan L CoxDepartment of Physics, Ohio State University, Columbus, OH, USA.
Fan XuanCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA.ORCID 0000-0002-8070-3309
Mohamad ZandianDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-4967-6867
Karina BarbosaTumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID 0000-0002-6233-3332
Sujita KhanalTumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Qiong TongDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
Yi ZhangDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0001-8170-9983
Pan ZhangTumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Amit SinhaBasepair Inc, New York, NY, USA.
Stefan K BohlanderLeukaemia and Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-2202-9088
Xiaobing ShiCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA.ORCID 0000-0001-5242-8189
Hong WenCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA.ORCID 0000-0001-8739-4572
Michael G PoirierDepartment of Physics, Ohio State University, Columbus, OH, USA.
Aniruddha J DeshpandeTumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. adeshpande@sbpdiscovery.org.ORCID 0000-0002-5240-9356
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. tatiana.kutateladze@cuanschutz.edu.ORCID 0000-0001-7375-6990
Sanford Burnham Prebys Medical Discovery Institute · USUniversity of Colorado Denver · USVan Andel Institute · USThe Ohio State University · USAltair Engineering (United States) · USUniversity of Auckland · NZUniversity of Colorado Anschutz Medical Campus · US
Funding
Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2MTargeting acetylated histone H4 by MLL4R01AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2021 to 2025
$2.1MMolecular analysis of ASH1LR01CA252707 · NCI · UNIVERSITY OF COLORADO DENVER · PI TATIANA G KUTATELADZE · 2020 to 2026
$1.9MDissecting functional cooperation among subunits in a catalytic ribonucleoproteinR01GM120582 · NIGMS · OHIO STATE UNIVERSITY · PI GOPALAN, VENKAT · 2016 to 2019
$1.9MThe role of JADE in HBO complexesR01HL151334 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.8MEpigenetic mechanisms for regulation of p300R01GM135671 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.4MUnderstanding how two related mammalian histone acetyl transferase co-activators, SAGA and ATAC, differentially regulate chromatin dynamics and transcriptionR01GM131626 · NIGMS · OHIO STATE UNIVERSITY · PI POIRIER, MICHAEL GUY · 2019 to 2021
$1.3MInterdomain crosstalk in MORC3R01GM125195 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2017 to 2021
$1.3MRegulatory Mechanisms of Linker Histones and Their Post-Translational ModificationsR01GM121966 · NIGMS · OHIO STATE UNIVERSITY · PI POIRIER, MICHAEL GUY · 2017 to 2020
$1.2MThe role of AF10 in normal and leukemic hematopoiesisR00CA154880 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI DESHPANDE, ANIRUDDHA J. · 2015 to 2017
$747kTargeting acetylated histone H4 by MLL4R56AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2020
$512kThe role of AF10 in normal and leukemic hematopoiesisK99CA154880 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI DESHPANDE, ANIRUDDHA J. · 2011 to 2012
$309kNCI NIH HHS K99 CA154880NCI NIH HHS P30 CA030199NCI NIH HHS R00 CA154880NCI NIH HHS R01 CA252707NHLBI NIH HHS R01 HL151334NIA NIH HHS R01 AG067664NIA NIH HHS R56 AG067664NIGMS NIH HHS R01 GM120582NIGMS NIH HHS R01 GM121966NIGMS NIH HHS R01 GM125195NIGMS NIH HHS R01 GM131626NIGMS NIH HHS R01 GM135671
Abstract
Chromosomal translocations of the AF10 (or MLLT10) gene are frequently found in acute leukemias. Here, we show that the PZP domain of AF10 (AF10
Indexed as
Acute DiseaseAnimalsCarcinogenesisCell Transformation, NeoplasticChromatinHEK293 CellsHistonesHumansLeukemia, Myeloid, AcuteMethylationMiceModels, MolecularMonomeric Clathrin Assembly ProteinsNucleosomesProtein ConformationTranscription FactorsChromatinHistonesMLLT10 protein, humanMllt10 protein, mouseMonomeric Clathrin Assembly ProteinsNucleosomesPICALM protein, humanTranscription Factors
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