ArticleNature communications2021
Cell migration guided by long-lived spatial memory.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 92 citations in OpenAlex.
- Mechanical regulation of cell memory.Nature structural & molecular biology · 2026Review
- Fibronectin matrix remodelling modulates the active nematic dynamics of cancer-associated fibroblasts.Nature materials · 2026Article
- Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton.Nature materials · 2026Article
- Matrix Mechanics Governs Mechano-Metabolic Adaptation across Cancer Grades in Bladder Spheroids.ACS applied materials & interfaces · 2026Article
- Review
- Flips reveal the universal impact of memory on random explorations.Nature communications · 2025Article
- Super-resolution microscopy reveals glioma cell footprints and exosome deposits.Cell adhesion & migration · 2025Article
- Unlocking the therapeutic potential of cellular mechanobiology.Science advances · 2025Review
- Self-propulsive active nematics.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Migratory responses in enucleated cells: The forces driving the locomotion movement of unicellular organisms.PNAS nexus · 2025Article
- Frictiotaxis underlies focal adhesion-independent durotaxis.Nature communications · 2025Article
- Durotaxis and extracellular matrix degradation promote the clustering of cancer cells.iScience · 2025Article
- Divergence in cellular markers observed in single-cell transcriptomics datasets between cultured primary trabecular meshwork cells and tissues.Scientific data · 2025Article
- Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment.Science advances · 2024Article
- Deposited footprints let cells switch between confined, oscillatory, and exploratory migration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Systemic cellular migration: The forces driving the directed locomotion movement of cells.PNAS nexus · 2024Article
- To be or not to be - Decoding the Trabecular Meshwork Cell Identity.bioRxiv : the preprint server for biology · 2024Article
- Size-dependent self-avoidance enables superdiffusive migration in macroscopic unicellulars.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Canonical and non-canonical integrin-based adhesions dynamically interconvert.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Living cells actively migrate in their environment to perform key biological functions-from unicellular organisms looking for food to single cells such as fibroblasts, leukocytes or cancer cells that can shape, patrol or invade tissues. Cell migration results from complex intracellular processes that enable cell self-propulsion, and has been shown to also integrate various chemical or physical extracellular signals. While it is established that cells can modify their environment by depositing biochemical signals or mechanically remodelling the extracellular matrix, the impact of such self-induced environmental perturbations on cell trajectories at various scales remains unexplored. Here, we show that cells can retrieve their path: by confining motile cells on 1D and 2D micropatterned surfaces, we demonstrate that they leave long-lived physicochemical footprints along their way, which determine their future path. On this basis, we argue that cell trajectories belong to the general class of self-interacting random walks, and show that self-interactions can rule large scale exploration by inducing long-lived ageing, subdiffusion and anomalous first-passage statistics. Altogether, our joint experimental and theoretical approach points to a generic coupling between motile cells and their environment, which endows cells with a spatial memory of their path and can dramatically change their space exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.