Evidence map›Paper›PMID 34226519›Full record

ArticleCell death & disease2021

The intrinsic role and mechanism of tumor expressed-CD38 on lung adenocarcinoma progression.

Long Gao, Yuan Liu, Xiaohong Du, Sai Ma, Minmin Ge, Haijun Tang, Chenfeng Han, Xin Zhao, Yanbin Liu, Yun Shao and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Expression of CD38Scientific reports · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. International journal of molecular sciences · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Long GaoInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Yuan LiuInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Xiaohong DuInstitute of Clinical Medicine Research, the Affiliated Suzhou Hospital of Nanjing Medical University; Suzhou Science and Technology Town Hospital, Suzhou, China.
Sai MaInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Minmin GeInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Haijun TangInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Chenfeng HanInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Xin ZhaoInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Yanbin LiuInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Yun ShaoInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Zhao WuInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Lianjun ZhangInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Fang MengInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China. onionmf@163.com.ORCID 0000-0001-8788-5224
F Xiao-Feng QinInstitute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China. fqin1@foxmail.com.ORCID 0000-0002-5395-0304
Chinese Academy of Medical Sciences & Peking Union Medical College · CNSuzhou Municipal Hospital · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31800726National Natural Science Foundation of China (National Science Foundation of China) 81701567National Natural Science Foundation of China (National Science Foundation of China) 81773058
6 · The paper itself

Abstract

It has been recently reported that CD38 expressed on tumor cells of multiple murine and human origins could be upregulated in response to PD-L1 antibody therapy, which led to dysfunction of tumor-infiltrating CD8

Indexed as

A549 CellsAdenocarcinoma of LungADP-ribosyl Cyclase 1AnimalsCalcium SignalingCarcinoma, Lewis LungCell MovementCell ProliferationCyclic ADP-RiboseDatabases, GeneticDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansKelch-Like ECH-Associated Protein 1Lung NeoplasmsADP-ribosyl Cyclase 1CD38 protein, humanCyclic ADP-RiboseKEAP1 protein, humanKelch-Like ECH-Associated Protein 1Membrane GlycoproteinsNFE2L2 protein, humanNF-E2-Related Factor 2TRPM2 protein, humanTRPM Cation Channels

Identifiers

PMID34226519
PMCPMC8256983
OpenAlexW3181223459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.