ArticleTranslational psychiatry2021
Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Cerebral small vessel disease and cognition in older adults across the neurodegenerative spectrum: insights from the COMPASS-ND study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Trajectories of pain and cognitive function: 22 years of evidence in mid-to-later life.medRxiv : the preprint server for health sciences · 2026Article
- Cerebral small vessel disease score associated with brain hypoperfusion predicts cognitive decline: a longitudinal study.BMC medical imaging · 2025Article
- Association of Intracranial Plaque Features with the Severity of White Matter Hyperintensities in Middle-Aged and Older Community-Dwelling Adults.Biomedicines · 2025Article
- Disrupted Brain Structure-Function Coupling and Its Mediating Effects on the Associations Between Cerebral Small Vessel Disease Burden and Cognitive Dysfunction.CNS neuroscience & therapeutics · 2025Article
- Small vessel disease contributions to acute delirium: a pilot feasibility MRI study.Age and ageing · 2025Article
- Modulatory Effects of Hypertension on Aging-Related White Matter Hyperintensities: A Comparative Study Among Stroke Patients and Stroke-Free Community-Based Cohort.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Middle-age cerebral small vessel disease and cognitive function in later life: a population-based prospective cohort study.The Lancet regional health. Western Pacific · 2025Article
- Executive functions and processing speed in covert cerebral small vessel disease.European journal of neurology · 2025Article
- Post-stroke cognitive impairment and fatigue in patients with white matter hyperintensities. A prospective cohort study.Cerebral circulation - cognition and behavior · 2025Article
- Association between intercellular adhesion molecule-1 to depression and blood-brain barrier penetration in cerebellar vascular disease.World journal of psychiatry · 2024Article
- Factors Associated With Post-Stroke Cognitive Impairment: A Narrative Review.Brain & NeuroRehabilitation · 2024Review
- Establishment and evaluation of a clinical prediction model for cognitive impairment in patients with cerebral small vessel disease.BMC neuroscience · 2024Article
- Progression of white matter hyperintensities is related to blood pressure increases and global cognitive decline - A registered report.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Development and validation of a nomogram predictive model for cognitive impairment in cerebral small vessel disease: a comprehensive retrospective analysis.Frontiers in neurology · 2024Article
- Trade-offs among brain structural network characteristics across the cognitive decline process in cerebral small vessel disease.Frontiers in aging neuroscience · 2024Article
- Trends in cognitive function before and after stroke in China.BMC medicine · 2023Article
- Association between cumulative smoking exposure and cognitive decline in non-demented older adults: NEDICES study.Scientific reports · 2023Article
- Neighbourhood deprivation across eight decades and late-life cognitive function in the Lothian Birth Cohort 1936: a life-course study.Age and ageing · 2023Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
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Abstract
Slowed processing speed is considered a hallmark feature of cognitive decline in cerebral small vessel disease (SVD); however, it is unclear whether SVD's association with slowed processing might be due to its association with overall declining general cognitive ability. We quantified the total MRI-visible SVD burden of 540 members of the Lothian Birth Cohort 1936 (age: 72.6 ± 0.7 years; 47% female). Using latent growth curve modelling, we tested associations between total SVD burden at mean age 73 and changes in general cognitive ability, processing speed, verbal memory and visuospatial ability, measured at age 73, 76, 79 and 82. Covariates included age, sex, vascular risk and childhood cognitive ability. In the fully adjusted models, greater SVD burden was associated with greater declines in general cognitive ability (standardised β: -0.201; 95% CI: [-0.36, -0.04]; p
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