Evidence map›Paper›PMID 34226506›Full record

ArticleTranslational psychiatry2021

Genome-wide association study of stimulant dependence.

Jiayi Cox, Richard Sherva, Leah Wetherill, Tatiana Foroud, Howard J Edenberg, Henry R Kranzler, Joel Gelernter, Lindsay A Farrer

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jiayi CoxDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02118, USA.
Richard ShervaDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02118, USA.
Leah WetherillDepartments of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Tatiana ForoudDepartments of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID 0000-0002-5549-2212
Howard J EdenbergDepartments of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID 0000-0003-0344-9690
Henry R KranzlerPerelman School of Medicine, University of Pennsylvania and VISN 4 MIRECC, Crescenz VAMC, Philadelphia, PA, 19104, USA.ORCID 0000-0002-1018-0450
Joel GelernterDepartments of Psychiatry, Genetics and Neuroscience, Yale School of Medicine, New Haven, CT, 06511, USA.ORCID 0000-0002-4067-1859
Lindsay A FarrerDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02118, USA. farrer@bu.edu.ORCID 0000-0001-5533-4225
Boston University · USIndiana University School of MedicineMental Illness Research, Education and Clinical Centers · USYale University · US

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7M
Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI John H. Krystal · 2001 to 2026
$43.7M
Sex-specific analysis of opioid dependence GWAS and beyondR01DA012690 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2000 to 2017
$14.0M
GENETICS OF COCAINE DEPENDENCER01DA012849 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1999 to 2010
$11.5M
Linkage Disequilibrium Studies of Alcohol DependenceR01AA011330 · NIAAA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1997 to 2013
$6.4M
Genomewide Association Study of Cocaine Dependence in two PopulationsRC2DA028909 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2009 to 2010
$4.2M
Genetics of Cocaine DependenceR01DA018432 · NIDA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KRANZLER, HENRY RICHARD · 2006 to 2010
$3.5M
Genetics of Alcohol Dependence in African-AmericansR01AA017535 · NIAAA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2009 to 2013
$3.0M
GENOTYPING FOR LOCATING HUMAN DISEASE GENESN01HG065403 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID L · 1996 to 2000
$1.7M
NHGRI NIH HHS N01 HG065403NIAAA NIH HHS P50 AA012870NIAAA NIH HHS R01 AA011330NIAAA NIH HHS R01 AA017535NIAAA NIH HHS U10 AA008401NIDA NIH HHS R01 DA012690NIDA NIH HHS R01 DA012849NIDA NIH HHS R01 DA018432NIDA NIH HHS RC2 DA028909
6 · The paper itself

Abstract

Stimulant dependence is heritable, but specific genetic factors underlying the trait have not been identified. A genome-wide association study for stimulant dependence was performed in a discovery cohort of African- (AA) and European-ancestry (EA) subjects ascertained for genetic studies of alcohol, opioid, and cocaine use disorders. The sample comprised individuals with DSM-IV stimulant dependence (393 EA cases, 5288 EA controls; 155 AA cases, 5603 AA controls). An independent cohort from the family-based Collaborative Study on the Genetics of Alcoholism (532 EA cases, 7635 EA controls; 53 AA cases, AA 3352 controls) was used for replication. One variant in SLC25A16 (rs2394476, p = 3.42 × 10

Indexed as

Genome-Wide Association StudySubstance-Related DisordersAutoantigensBlack or African AmericanGenetic Predisposition to DiseaseHumansMembrane Transport ProteinsPolymorphism, Single NucleotideWhite PeopleAutoantigensMembrane Transport ProteinsSLC25A16 protein, human

Identifiers

PMID34226506
PMCPMC8257618
OpenAlexW3177792764

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.