Evidence map›Paper›PMID 34226493›Full record

ArticleTranslational psychiatry2021

ErbB4 promotes inhibitory synapse formation by cell adhesion, independent of its kinase activity.

Bin Luo, Ziyang Liu, Dong Lin, Wenbing Chen, Dongyan Ren, Zheng Yu, Mingtao Xiong, Changqin Zhao, Erkang Fei, Baoming Li

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

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  11. Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Bin Luo *School of Life Sciences, Nanchang University, Nanchang, China.ORCID 0000-0003-4989-8563
Ziyang Liu *School of Life Sciences, Nanchang University, Nanchang, China.
Dong LinSchool of Life Sciences, Nanchang University, Nanchang, China.
Wenbing ChenSchool of Life Sciences, Nanchang University, Nanchang, China.
Dongyan RenSchool of Life Sciences, Nanchang University, Nanchang, China.
Zheng YuInstitute of Life Science, Nanchang University, Nanchang, China.
Mingtao XiongSchool of Life Sciences, Nanchang University, Nanchang, China.
Changqin ZhaoSchool of Life Sciences, Nanchang University, Nanchang, China.
Erkang FeiSchool of Life Sciences, Nanchang University, Nanchang, China. fek@ncu.edu.cn.ORCID 0000-0002-3581-9521
Baoming LiSchool of Life Sciences, Nanchang University, Nanchang, China. bmli@hznu.edu.cn.
Nanchang University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31771142National Natural Science Foundation of China (National Science Foundation of China) 31971035National Natural Science Foundation of China (National Science Foundation of China) 81460215
6 · The paper itself

Abstract

The precise control of the nervous system function under the vitality of synapses is extremely critical. Efforts have been taken to explore the underlying cellular and molecular mechanisms for synapse formation. Cell adhesion molecules have been found important for synapse assembly in the brain. Many trans-adhesion complexes have been identified to modulate excitatory synapse formation. However, little is known about the synaptogenic mechanisms for inhibitory synapses. ErbB4 is a receptor tyrosine kinase enriched in interneurons. Here, we showed that overexpressing ErbB4 in HEK293T cells induced gephyrin or GABA

Indexed as

NeurogenesisSynapsesAnimalsCell AdhesionHEK293 CellsHippocampusHumansMiceReceptor, ErbB-4ERBB4 protein, humanErbb4 protein, mouseReceptor, ErbB-4

Identifiers

PMID34226493
PMCPMC8257755
OpenAlexW3179736428

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.