ArticleTranslational psychiatry2021
Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Investigating the causal associations between neuroticism, schizophrenia, and cardiovascular diseases using Mendelian randomization.European archives of psychiatry and clinical neuroscience · 2026Article
- Type A and Type D Personality in Cardiovascular Health: A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Depression, Anxiety, and Bipolar Disorder and Atherosclerosis.Current atherosclerosis reports · 2026Review
- Association between neuroticism and cosmetic mammoplasty: Results from a bidirectional Mendelian randomization study.Medicine · 2026Article
- Coronary heart disease offspring: identification of short-term cardiovascular risk factors and construction of digital technology-integrated personalized health education pathways.BMC cardiovascular disorders · 2026Article
- Association between neuroticism, genetic susceptibility, and peripheral artery disease risk: a prospective study in UK Biobank.European archives of psychiatry and clinical neuroscience · 2026Article
- Self-harming behavior linked to earlier onset of cardiovascular disease in severe mental disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Neuroticism and sudden cardiac death: a prospective cohort study from UK biobank.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Association between personality profiles and motoric cognitive risk syndrome in community-dwelling older adults: a person-centered approach.BMC psychiatry · 2025Article
- Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors.Communications biology · 2024Article
- Analysis of the Influence of Personality Traits on the Level of Knowledge and Health Behaviours of Cardiac Patients.Journal of clinical medicine · 2024Article
- Article
- Neuroticism and the Risk of Atrial Fibrillation: An Observational Epidemiologic and Mendelian Randomization Study.JACC. Asia · 2024Article
- High neuroticism is associated with common late adverse effects in a nationwide sample of long-term breast cancer survivors.Breast cancer research and treatment · 2023Article
- Neuroticism personality traits are linked to adverse cardiovascular phenotypes in the UK Biobank.European heart journal. Cardiovascular Imaging · 2023Article
- Personality traits and cardiovascular diseases: is it about 'don't worry, be happy', or is this a deeper underlying problem?European heart journal. Cardiovascular Imaging · 2023Article
- A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism.Molecular brain · 2022Article
- Dissecting the Association of Genetically Predicted Neuroticism with Coronary Artery Disease: A Two-Sample Mendelian Randomization Study.Journal of personalized medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and coronary artery disease (CAD). The conditional/conjunctional false discovery rate method (cond/conjFDR) was applied to genome wide association study (GWAS) summary statistics on neuroticism (n = 432,109), CAD (n = 184,305) and 12 CVD risk factors (n = 188,577-339,224) to investigate genetic overlap between neuroticism and CAD and CVD risk factors. CondFDR analyses identified 729 genomic loci associated with neuroticism after conditioning on CAD and CVD risk factors. The conjFDR analyses revealed 345 loci jointly associated with neuroticism and CAD (n = 30), body mass index (BMI) (n = 96) or another CVD risk factor (n = 1-60). Several loci were jointly associated with neuroticism and multiple CVD risk factors. Seventeen of the shared loci with CAD and 61 of the shared loci with BMI are novel for neuroticism. 21 of 30 (70%) neuroticism risk alleles were associated with higher CAD risk. Functional analyses of the genes mapped to the shared loci implicated cell division, nuclear receptor, elastic fiber formation as well as starch and sucrose metabolism pathways. Our results indicate polygenic overlap between neuroticism and CAD and CVD risk factors, suggesting that genetic factors may partly cause the comorbidity. This gives new insight into the shared molecular genetic basis of these conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.