Evidence map›Paper›PMID 34226299›Full record

ArticleAging2021

miR-144-3p inhibited the growth, metastasis and epithelial-mesenchymal transition of colorectal adenocarcinoma by targeting ZEB1/2.

Taiyuan Li, Cheng Tang, Zhixiang Huang, Lingling Yang, Hua Dai, Bo Tang, Benping Xiao, Jianfeng Li, Xiong Lei

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Taiyuan LiDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Cheng TangDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Zhixiang HuangDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Lingling YangDepartment of Gastroenterology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Hua DaiDepartment of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Bo TangDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Benping XiaoDepartment of General Surgery, Jiangxi Pingxiang People's Hospital, Pingxiang 337000, Jiangxi, China.
Jianfeng LiDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Xiong LeiDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
First Affiliated Hospital of Nanchang University · CNNanchang University · CNJiangxi Pingxiang People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

miR-144-3p is aberrantly expressed in several types of human cancer and functions as a tumor suppressor by inhibiting metastasis. However, the clinical significance and biological function of miR-144-3p in colorectal adenocarcinoma (CRA) have yet to be elucidated. Here we reported that miR-144-3p expression level was significantly down-regulated in CRA tissues compared with matched noncancerous colorectal mucosae tissues. Low miR-144-3p expression was correlated with adverse clinicopathologic characteristics and poor prognosis of CRA patients. Cox regression analysis showed that low miR-144-3p expression was an independent risk factor for DFS and OS in CRA.

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overAgingAnimalsCell Line, TumorCell MovementCell ProliferationColorectal NeoplasmsDown-RegulationEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansIntestinal MucosaMicroRNAsMIRN144 microRNA, humanZEB1 protein, humanZEB2 protein, humanZinc Finger E-box-Binding Homeobox 1Zinc Finger E-box Binding Homeobox 2colorectal cancerepithelial-mesenchymal transitionmetastasismiR-144-3pZEB1/2

Identifiers

PMID34226299
PMCPMC8312459
OpenAlexW3178276246

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.