Evidence map›Paper›PMID 34226281›Full record

ArticleJournal for immunotherapy of cancer2021

Expression of KLRG1 and CD127 defines distinct CD8

Hongyan Wu, Xinyi Tang, Hyo Jin Kim, Shahrzad Jalali, Joshua C Pritchett, Jose C Villasboas, Anne J Novak, Zhi-Zhang Yang, Stephen M Ansell

Open access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Immune profiling identifies CD161Journal of translational medicine · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. The role of KLRG1: a novel biomarker and new therapeutic target.Cell communication and signaling : CCS · 2024
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hongyan WuDepartment of Immunology, Medical College, China Three Gorges University, Yichang, Hubei, People's Republic of China.
Xinyi TangDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Hyo Jin KimDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Shahrzad JalaliDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Joshua C PritchettDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Jose C VillasboasDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Anne J NovakDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Zhi-Zhang YangDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA yang.zhizhang@mayo.edu ansell.stephen@mayo.edu.ORCID 0000-0002-1468-2300
Stephen M AnsellDivision of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA yang.zhizhang@mayo.edu ansell.stephen@mayo.edu.
Mayo Clinic in Arizona · USChina Three Gorges University · CN

Funding

The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI LENTZ, STEVEN R · 2002 to 2021
$45.7M
NCI NIH HHS P50 CA097274
6 · The paper itself

Abstract

backgroundCD8

methodsTo characterize the phenotype of KLRG1/CD127-defined CD8

resultsWe found that intratumoral CD8

conclusionsTaken together, these results reveal not only a biological and prognostic role for KLRG1/CD127-defined CD8

Indexed as

CD8-Positive T-LymphocytesCell DifferentiationFemaleHumansInterleukin-7 Receptor alpha SubunitLectins, C-TypeLymphoma, FollicularReceptors, ImmunologicTreatment OutcomeTumor MicroenvironmentIL7R protein, humanInterleukin-7 Receptor alpha SubunitKLRG1 protein, humanLectins, C-TypeReceptors, Immunologiccellularimmunityimmunologic memorylymphocytesT-lymphocytestumor-infiltratingtumor microenvironment

Identifiers

PMID34226281
PMCPMC8258669
OpenAlexW3181389722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.