Evidence map›Paper›PMID 34226210›Full record

ArticleBMJ open2021

Substance use disorders and adherence to antituberculosis medications in Southwest Ethiopia: a prospective cohort study.

Matiwos Soboka, Markos Tesfaye, Kristina Adorjan, Wolfgang Krahl, Elias Tesfaye, Yimenu Yitayih, Ralf Strobl, Eva Grill

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In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matiwos SobokaDepartment of Psychiatry, Medical Faculty, Jimma University, Jimma, Ethiopia matiwos2004@yahoo.com.ORCID 0000-0003-2820-0947
Markos TesfayeCenter for International Health, Ludwig Maxmilians University, Munich, Germany.
Kristina AdorjanCenter for International Health, Ludwig Maxmilians University, Munich, Germany.
Wolfgang KrahlCenter for International Health, Ludwig Maxmilians University, Munich, Germany.
Elias TesfayeDepartment of Psychiatry, Medical Faculty, Jimma University, Jimma, Ethiopia.
Yimenu YitayihDepartment of Psychiatry, Medical Faculty, Jimma University, Jimma, Ethiopia.ORCID 0000-0002-0300-394X
Ralf StroblInstitute for Medical Information Processing, Biometry and Epidemiology,Ludwig Maximilians University Muenchen, Munich, Germany.
Eva GrillCenter for International Health, Ludwig Maxmilians University, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn Ethiopia, little is known about the association between substance use disorders and adherence to antituberculosis (anti-TB) medications. Therefore, the objective of this study was to assess the effect of substance use disorders on adherence to anti-TB medications in Southwest Ethiopia.

designProspective cohort study. SETTINGS: Patients were recruited from 22 health centres and four hospitals in Southwest Ethiopia.

participantsThis study was conducted among 268 patients with TB, aged 18-80 in Southwest Ethiopia between October 2017 and October 2018. At baseline, patients who were exposed substance use disorders (134 patients) and unexposed to substance use disorders (134 patients) were recruited. Patients were followed for 6 months, and data were collected on three occasions.

main outcome measureAdherence to anti-TB medications.

resultsPatients with substance use disorders had consistently higher prevalence of non-adherence than those without, 16.4% versus 3.0% at baseline, 41.7% versus 14.4% at 2-month follow-up and 45.7% versus 10.8% at 6-month follow-up assessments. Patients with khat use disorder were 3.8 times more likely to be non-adherent to anti-TB medications than patients without khat use disorder (Adjusted odds ratio (aOR)=3.8, 95% CI 1.8 to 8.0). Patients who had alcohol use disorder (AUD) were also 3.2 times likely to have poor adherence compared with their counterparts (aOR=3.2, 95% CI 1.6 to 6.6). In addition, being educated (aOR=4.4, 95% CI 1.7 to 11.3), and being merchant (aOR=6.1, 95% CI 1.2 to 30.8) were associated with non-adherence to anti-TB medications.

conclusionKhat and AUDs predict greater likelihood of non-adherence to anti-TB medication. This implies the need to integrate the management for substance use disorders into the existing TB treatment services.

Indexed as

Antitubercular AgentsSubstance-Related DisordersCathaCross-Sectional StudiesEthiopiaHumansMedication AdherenceProspective StudiesAntitubercular Agentsclinical pharmacologyinfectious diseasessubstance misusetuberculosis

Identifiers

PMID34226210
PMCPMC8258551

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.