ArticleJournal of the Academy of Nutrition and Dietetics2022
The Gut Microbiome Is Associated with Circulating Dietary Biomarkers of Fruit and Vegetable Intake in a Multiethnic Cohort.
Article in Journal of the Academy of Nutrition and Dietetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Nutritional factors and cross-national postpartum depression prevalence: an updated meta-analysis and meta-regression of 412 studies from 46 countries.Frontiers in psychiatry · 2023Pooled it
- Dietary Carotenoid Intake, Gut Microbial Diversity, and Community Composition in Latino Emerging Adults.Microorganisms · 2026Article
- The gut microbiome connects nutrition and human health.Nature reviews. Gastroenterology & hepatology · 2025Review
- The gut-liver axis links the associations between serum carotenoids and non-alcoholic fatty liver in a 7.8-year prospective study.Hepatobiliary surgery and nutrition · 2025Article
- Key Taxa of the Gut Microbiome Associated with the Relationship Between Environmental Sensitivity and Inflammation-Related Biomarkers.Microorganisms · 2025Article
- Risk and Protective Factors of COPD Among Smokers: A Cross-Sectional Study Using NHANES Database.International journal of chronic obstructive pulmonary disease · 2025Article
- The Significance of Plant Nutrition in the Creation of the Intestinal Microbiota-Prevention of Chronic Diseases: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Vegetable Salad Improves Lipid and Glucose Metabolism and Enhances Absorption of Specific Nutrients in Vegetables.Foods (Basel, Switzerland) · 2024Review
- Dietary Habits and Depression in Community-Dwelling Chinese Older Adults: Cross-Sectional Analysis of the Moderating Role of Physical Exercise.Nutrients · 2024Article
- Vegetables, fruits, and berries - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2024Article
- Association between dietary carotenoids intake and chronic constipation in American men and women adults: a cross-sectional study.BMC public health · 2023Article
- Sources, dynamics in vivo, and application of astaxanthin and lutein in laying hens: A review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Review
- Review
- Bacterial DNAemia in Older Participants and Nonagenarian Offspring and Association With Redox Biomarkers: Results From MARK-AGE Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Fecal Metabolites as Biomarkers for Predicting Food Intake by Healthy Adults.The Journal of nutrition · 2023Article
- A personalized diet intervention improves depression symptoms and changes microbiota and metabolite profiles among community-dwelling older adults.Frontiers in nutrition · 2023Article
- Grain, Gluten, and Dietary Fiber Intake Influence Gut Microbial Diversity: Data from the Food and Microbiome Longitudinal Investigation.Cancer research communications · 2023Article
- The Gut Microbiome among Postmenopausal Latvian Women in Relation to Dietary Habits.Nutrients · 2022Article
- A Guide to Dietary Pattern-Microbiome Data Integration.The Journal of nutrition · 2022Review
- What Is the Current Direction of the Research on Carotenoids and Human Health? An Overview of Registered Clinical Trials.Nutrients · 2022Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundResults from observational studies suggest high diet quality favorably influences the human gut microbiome. Fruit and vegetable consumption is often a key contributor to high diet quality.
objectiveTo evaluate measures of gut bacterial diversity and abundance in relation to serum biomarkers of fruit and vegetable intake.
designSecondary analysis of cross-sectional data. PARTICIPANTS AND
settingMen and women from Los Angeles, CA, and Hawai'i who participated in the Multiethnic Cohort-Adiposity Phenotype Study from 2013 to 2016 (N = 1,709).
main outcome measuresGut microbiome diversity and composition in relation to dietary biomarkers. STATISTICAL ANALYSIS: Carotenoid (beta carotene, alpha carotene, cryptoxanthins, lutein, lycopene, and zeaxanthin), tocopherol (α, β + γ, and δ), and retinol concentrations were assessed in serum. The α and β diversity and composition of the gut microbiome were classified based on 16S rRNA gene sequencing of bacterial DNA from self-collected fecal samples. Global differences in microbial community profiles in relation dietary biomarkers were evaluated using multivariable permutational analysis of variance. Associations of α diversity (Shannon index), β diversity (weighted and unweighted UniFrac) with center log-ratio-transformed phyla and genera abundances were evaluated using linear regression, adjusted for covariates.
resultsIncreasing total carotenoid, beta carotene, alpha carotene, cryptoxanthin, and lycopene concentrations were associated with higher gut bacterial diversity (Shannon Index) (P < 0.001). Total tocopherol, α-tocopherol, and δ-tocopherol concentrations contributed significantly to more than 1% of the microbiome variation in gut bacterial community: total tocopherol: 1.74%; α-tocopherol: 1.70%; and δ-tocopherol: 1.16% (P < 0.001). Higher total carotenoid was associated with greater abundance of some genera relevant for microbial macronutrient metabolism (P < 0.001).
conclusionsObjective biomarkers of fruit and vegetable intake, particularly carotenoids, were favorably associated with gut bacterial composition and diversity in this multiethnic population. These observations provide supportive evidence that fruit and vegetable intake is related to gut bacterial composition; more work is needed to elucidate how this influences host health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.