ReviewHandbook of clinical neurology2021
Disrupted circadian rhythms and mental health.
Review in Handbook of clinical neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Research Progress on Light Therapy to Improve Depressive Symptoms of Bipolar Depression.Actas espanolas de psiquiatria · 2026Review
- Association of screen time and chronotype with depression and anxiety symptoms among Chinese adolescents.Annals of general psychiatry · 2026Article
- Associations of meal timing and sleep timing with premenstrual syndrome and dysmenorrhea in Japanese women: a cross-sectional study.Frontiers in nutrition · 2026Article
- When the biological clock is disordered: circadian rhythm disruption as a core pathophysiological mechanism in anxiety and depression.Frontiers in psychiatry · 2026Review
- Slow wave electroencephalogram spectral properties during adaptation of a new light dark cycle in cynomolgus monkeys.Sleep advances : a journal of the Sleep Research Society · 2026Article
- The network linking daytime sleepiness, chronotype, and emotional distress is bridged by anxiety and depression in young adults.Scientific reports · 2025Article
- Insomnia mediates the longitudinal association between loneliness and burnout among nurses.Scientific reports · 2025Article
- Temporal Tendencies: Exploring the Impact of Chronotype Timing on Youth Depression Risk.Research on child and adolescent psychopathology · 2025Article
- Feasibility of an At-Home Experimental Circadian Misalignment Induction for Adolescents.Clocks & sleep · 2025Article
- Sleep and psychiatric disorders: Bidirectional interactions and shared neurobiological mechanisms.PLOS mental health · 2025Review
- Circadian-independent light regulation of mammalian metabolism.Nature metabolism · 2024Review
- Therapeutic Aspects of Circadian Rhythms.Biomolecules · 2023Article
- Being a morning man has causal effects on the cerebral cortex: a Mendelian randomization study.Frontiers in neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
During the evolution of life, the temporal rhythm of our rotating planet was internalized in the form of circadian rhythms. Circadian rhythms are ~24h internal manifestations that drive daily patterns of physiology and behavior. These rhythms are entrained (synchronized) to the external environment, primarily by the light-dark cycle, and precisely controlled via molecular clocks located within the suprachiasmatic nucleus of the hypothalamus. Misalignment and/or disruption of circadian rhythms can have detrimental consequences for human health. Indeed, studies suggest strong associations between mental health and circadian rhythms. However, direct interactions between mood regulation and the circadian system are just beginning to be uncovered and appreciated. This chapter examines the relationship between disruption of circadian rhythms and mental health. The primary focus will be outlining the association between circadian disruption, in the form of night shift work, exposure to light at night, jet lag, and social jet lag, and psychiatric illness (i.e., anxiety, major depressive disorder, bipolar disorder, and schizophrenia). Additionally, we review animal models of disrupted circadian rhythms, which provide further evidence in support of a strong association between circadian disruption and affective responses. Finally, we discuss future directions for the field and suggest areas of study that require further investigation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.