ArticleeLife2021
Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria.Nature communications · 2022Pooled it
- Clinical impact of vivax malaria: A collection review.PLoS medicine · 2022Pooled it
- Sickle cell anaemia and severe Plasmodium falciparum malaria: a secondary analysis of the Transfusion and Treatment of African Children Trial (TRACT).The Lancet. Child & adolescent health · 2022Trial
- Program Evaluation of Community Case Management with Reactive Test and Treat for Malaria in a High-Transmission Setting.The American journal of tropical medicine and hygiene · 2025Article
- Aetiologies, neuroradiological features, and risk factors for mortality and long-term neurosequelae of febrile coma in Malawian children: a prospective cohort study.The Lancet. Global health · 2025Article
- A Qualitative Method To Assess a History of Cerebral Malaria in Malian Children.The American journal of tropical medicine and hygiene · 2025Article
- Article
- Artemisinin-resistant malaria.Clinical microbiology reviews · 2024Review
- Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria.PLoS genetics · 2023Article
- Using Malarial Retinopathy to Improve the Diagnosis of Pediatric Cerebral Malaria.The American journal of tropical medicine and hygiene · 2023Article
- Article
- Reducing misclassification bias in severe malaria research.Cell reports. Medicine · 2022Article
- Severe malaria.Malaria journal · 2022Review
- The assessment of antimalarial drug efficacy in vivo.Trends in parasitology · 2022Review
- Article
- Improving the diagnosis of severe malaria in African children using platelet counts and plasmaScience translational medicine · 2022Article
- The impact of malaria-protective red blood cell polymorphisms on parasite biomass in children with severe Plasmodium falciparum malaria.Nature communications · 2022Article
- Revisiting the malaria hypothesis: accounting for polygenicity and pleiotropy.Trends in parasitology · 2022Review
- Article
Corrections and comments
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Authors and funding
21 authors at 6 institutions in 4 countries.
Funding
Abstract
Severe falciparum malaria has substantially affected human evolution. Genetic association studies of patients with clinically defined severe malaria and matched population controls have helped characterise human genetic susceptibility to severe malaria, but phenotypic imprecision compromises discovered associations. In areas of high malaria transmission, the diagnosis of severe malaria in young children and, in particular, the distinction from bacterial sepsis are imprecise. We developed a probabilistic diagnostic model of severe malaria using platelet and white count data. Under this model, we re-analysed clinical and genetic data from 2220 Kenyan children with clinically defined severe malaria and 3940 population controls, adjusting for phenotype mis-labelling. Our model, validated by the distribution of sickle trait, estimated that approximately one-third of cases did not have severe malaria. We propose a data-tilting approach for case-control studies with phenotype mis-labelling and show that this reduces false discovery rates and improves statistical power in genome-wide association studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.