ArticleChinese neurosurgical journal2021
Quantified assessment of deep brain stimulation on Parkinson's patients with task fNIRS measurements and functional connectivity analysis: a pilot study.
Article in Chinese neurosurgical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Dynamic brain synergy uncovers functional neural coordination in Parkinson's disease under dopaminergic modulation.Journal of neuroengineering and rehabilitation · 2026Article
- Wireless closed-loop deep brain stimulation using microelectrode array probes.Journal of Zhejiang University. Science. B · 2024Review
- Functional Near-Infrared Spectroscopy in neurodegenerative disease: a review.Frontiers in neuroscience · 2024Review
- Decrease in walking ability with increased functional connectivity between multiple brain areas in Parkinson's disease: a functional near-infrared spectroscopy study.Frontiers in aging neuroscience · 2024Article
- Whole-Head Functional Near-Infrared Spectroscopy as an Ecological Monitoring Tool for Assessing Cortical Activity in Parkinson's Disease Patients at Different Stages.International journal of molecular sciences · 2022Article
- fNIRS-derived neurocognitive ratio as a biomarker for neuropsychiatric diseases.Neurophotonics · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDeep brain stimulation (DBS) has proved effective for Parkinson's disease (PD), but the identification of stimulation parameters relies on doctors' subjective judgment on patient behavior.
methodsFive PD patients performed 10-meter walking tasks under different brain stimulation frequencies. During walking tests, a wearable functional near-infrared spectroscopy (fNIRS) system was used to measure the concentration change of oxygenated hemoglobin (△HbO
resultsWe discovered that both the global and regional brain efficiency of all patients varied with stimulation parameters, and the DBS pattern enabling the highest brain efficiency was optimal for each patient, in accordance with the clinical assessments and DBS treatment decision made by the doctors.
conclusionsTask fNIRS assessments and brain functional connectivity analysis promise a quantified and objective solution for patient-specific optimization of DBS treatment.
trial registrationName: Accurate treatment under the multidisciplinary cooperative diagnosis and treatment model of Parkinson's disease. Registration number is ChiCTR1900022715. Date of registration is April 23, 2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.