Evidence map›Paper›PMID 34225758›Full record

ArticleMolecular brain2021

Disrupting the α7nAChR-NR2A protein complex exerts antidepressant-like effects.

Anlong Jiang, Ping Su, Shupeng Li, Albert H C Wong, Fang Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. LPS-induced impairment of NaMetabolic brain disease · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anlong JiangCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Ping SuCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Shupeng LiCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Albert H C WongCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Fang LiuCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada. fang.liu@camh.ca.ORCID 0000-0002-6742-1446
Centre for Addiction and Mental Health · CA

Funding

CIHR
6 · The paper itself

Abstract

Major depressive disorder (MDD) is associated with significant morbidity and mortality. Most antidepressant medications target the serotonin and norepinephrine transporters, but a significant minority of patients do not respond to treatment and novel therapeutic targets are needed. We previously identified a protein complex composed of the α7 nicotinic acetylcholine receptor (nAChR) and NMDA glutamate receptors (NMDARs), through which α7nAChR upregulates NMDAR function. Disruption of the α7nAChR-NMDAR complex with an interfering peptide blocked α7nAChR-mediated upregulation of NMDAR function and cue-induced reinstatement of nicotine seeking in rat models of relapse. Here we report that disrupting the α7nAChR-NMDAR complex with the interfering peptide also has antidepressant-like effects in the forced swim test (FST), a common rat behaviour screening test for antidepressant effects. Furthermore, the interfering peptide significantly increases extracellular signal-regulated kinase (ERK) activity in the animals subjected to the FST. Our results provide a novel potential therapeutic target for the development of new antidepressant medications.

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnimalsAntidepressive AgentsBrain-Derived Neurotrophic FactorExtracellular Signal-Regulated MAP KinasesGene Products, tatHippocampusMaleMotor ActivityPeptidesPhosphorylationProtein BindingRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSwimmingalpha7 Nicotinic Acetylcholine ReceptorAntidepressive AgentsBrain-Derived Neurotrophic FactorExtracellular Signal-Regulated MAP KinasesGene Products, tatPeptidesReceptors, N-Methyl-D-AspartateExtracellular signal-regulated kinase (ERK)Forced swim test (FST)Major depressive disorder (MDD)NMDA glutamate receptors (NMDARs)α7 Nicotinic acetylcholine receptor (α7nAChR)

Identifiers

PMID34225758
PMCPMC8256601
OpenAlexW3178324475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.