Evidence map›Paper›PMID 34225707›Full record

ArticleBMC oral health2021

Longitudinal assessment of salivary vitamin D binding protein during orthodontic tooth movement.

Nada Tashkandi, Yihong Zhao, Gabrielle Mitchell-Lee, Danielle Stephens, Michele Patel, Melih Motro, Leslie A Will, Alpdogan Kantarci

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nada TashkandiDepartment of Applied Oral Sciences, Forsyth Institute, 245 First St, Cambridge, MA, 02142, USA.
Yihong ZhaoDepartment of Applied Psychology, Center of Alcohol and Substance Use Studies, School of Applied and Professional Psychology, Rutgers University, New Brunswick, Piscataway, NJ, USA.
Gabrielle Mitchell-LeeDepartment of Orthodontics and Dentofacial Orthopedics, Boston University Henry M Goldman School of Dental Medicine, Boston, MA, USA.
Danielle StephensDepartment of Applied Oral Sciences, Forsyth Institute, 245 First St, Cambridge, MA, 02142, USA.
Michele PatelDepartment of Applied Oral Sciences, Forsyth Institute, 245 First St, Cambridge, MA, 02142, USA.
Melih MotroDepartment of Orthodontics and Dentofacial Orthopedics, Boston University Henry M Goldman School of Dental Medicine, Boston, MA, USA.
Leslie A WillDepartment of Orthodontics and Dentofacial Orthopedics, Boston University Henry M Goldman School of Dental Medicine, Boston, MA, USA.
Alpdogan KantarciDepartment of Applied Oral Sciences, Forsyth Institute, 245 First St, Cambridge, MA, 02142, USA. akantarci@forsyth.org.
Boston University · USHarvard University · USRutgers, The State University of New Jersey · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D is critical for bone physiology. In this study, we quantified Vitamin D Binding Protein (VitDBP) levels in saliva as a measure of Vitamin D during orthodontic tooth movement.

methodsIn this longitudinal study, saliva samples were collected from 73 orthodontic patients for 4 timepoints for the first six months of orthodontic treatment, along with dental casts at the beginning and the end of the study period. The saliva was measured for VitDBP as a biological marker for bone apposition and clinical tooth movement. We used the absolute change in Little's Irregularity Index as a quantitative measure for alignment. In addition, we measured the levels of alkaline phosphatase (ALP) in saliva as a marker of bone turnover.

resultsBoth low (< 2.75 ng/ml) and high (> 6.48 ng/ml) VitDBP levels were associated with reduced tooth movement. Significant (p < 0.05) seasonal changes in VitDBP using a two-season year model were found with lower levels observed in the summer (Apr-Sept) than in the winter (Oct-Mar).

conclusionsClinically significant orthodontic tooth movement is associated with an optimal range of VitDBP in saliva. Normal levels of VitDBP correlated with more orthodontic tooth movement, suggesting a "normal" range of salivary content of VitDBP. Given the strong trend that is independent of the confounding factors (ex. age, race or gender), the predictive value or salivary VitDBP for tooth movement should be studied in larger cohorts in future studies.

Indexed as

Tooth Movement TechniquesVitamin D-Binding ProteinBone RemodelingHumansLongitudinal StudiesSalivaVitamin D-Binding ProteinIrregularity IndexOrthodontic tooth movementVitamin DVitamin D Binding Protein

Identifiers

PMID34225707
PMCPMC8256539
OpenAlexW3178697128

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.