Evidence map›Paper›PMID 34225491›Full record

ArticlemBio2021

Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication.

Xueyan Zhang, Haojie Hao, Li Ma, Yecheng Zhang, Xiao Hu, Zhen Chen, Di Liu, Jianhui Yuan, Zhangli Hu, Wuxiang Guan

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Multidimensional mechanisms of SFTSV-host interactions: viral protein functions, mFrontiers in cellular and infection microbiology · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Targeting G9a-miScience · 2025
    Article
  16. Article
  17. Article
  18. METTL3: a multifunctional regulator in diseases.Molecular and cellular biochemistry · 2025
    Review
  19. An mNature communications · 2025
    Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xueyan ZhangCenter for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Haojie HaoCollege of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.
Li MaCenter for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Yecheng ZhangCenter for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Xiao HuCenter for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Zhen ChenCenter for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Di LiuCenter for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Jianhui YuanNanshan District Center for Disease Control and Prevention, Shenzhen, China.
Zhangli HuCollege of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.
Wuxiang GuanCenter for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Chinese Academy of Sciences · CNShenzhen University · CNShenzhen Nanshan Center for Chronic Disease Control · CN

Funding

Chinese Academy of Engineering 2020-ZD-15Chinese Academy of Sciences Key Project (CAS Key Project) 2020YJFK0107Ministry of Science and Technology (MOST) 2020YFC0845800
6 · The paper itself

Abstract

The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an ongoing global public crisis. Although viral RNA modification has been reported based on the transcriptome architecture, the types and functions of RNA modification are still unknown. In this study, we evaluated the roles of RNA N6-methyladenosine (m

Indexed as

AdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOCOVID-19Gene Expression RegulationHumansMethylationMethyltransferasesProtein Processing, Post-TranslationalRNA-Dependent RNA PolymeraseRNA, ViralSARS-CoV-2Virus ReplicationAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanMethyltransferasesMETTL3 protein, humanN-methyladenosineRNA-Dependent RNA PolymeraseRNA, Viralmethyltransferase-like 3N6-methyladenosinerespiratory syndrome coronavirus-2viral replication

Identifiers

PMID34225491
PMCPMC8437041
OpenAlexW3182080654

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.