Evidence map›Paper›PMID 34225436›Full record

ReviewZhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology2021

[Application of Mdr2 gene knockout mice in liver disease research].

M Li, J Ping, L M Xu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

M LiShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai201203, China Institute of Hepatology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
J PingShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai201203, China Institute of Hepatology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai 201203, China.
L M XuShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai201203, China Institute of Hepatology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai 201203, China.
Shanghai University of Traditional Chinese Medicine · CN

Funding

Special Scientific Research Project of "Innovation Training for Postgraduates" of Shanghai University of Traditional Chinese Medicine Y2021070
6 · The paper itself

Abstract

Mdr2 knockout mice is a liver disease model, which causes cholestasis due to the lack of phospholipids in the bile. At present, it is not only used for the study of human homologous MDR3 gene, but also widely used as an animal model of liver diseases such as primary sclerosing cholangitis, liver fibrosis, progressive familial intrahepatic cholestasis, liver cancer. Herein, we review the Mdr2 knockout mice physiological characteristics and its application in liver disease research.

Indexed as

Cholangitis, SclerosingCholestasis, IntrahepaticAnimalsATP Binding Cassette Transporter, Subfamily BDisease Models, AnimalGene Knockout TechniquesLiverMiceMice, KnockoutATP Binding Cassette Transporter, Subfamily BAnimal modelHepatic fibrosisLiver cancerPrimary sclerosing cholangitis

Identifiers

PMID34225436
PMCPMC12814779
OpenAlexW3177913704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.