Evidence map›Paper›PMID 34225423›Full record

ArticleZhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology2021

[Immune pathogenesis of primary biliary cholangitis].

M Y Zhang, J Zhao, H Xie, Q S Liang, Z S Zou, Y Sun

Open access · greenAbstract read
In one paragraph

Article in Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. [Exploring the research on the molecular mechanisms of autoimmune liver diseases].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

M Y ZhangDepartment of Liver Disease, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China Graduate School of PLA General Hospital, Beijing 100853, China.
J ZhaoDepartment of Liver Disease, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
H XieDepartment of Liver Disease, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Q S LiangDepartment of Liver Disease, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Z S ZouDepartment of Liver Disease, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Y SunDepartment of Liver Disease, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Chinese PLA General Hospital · CN

Funding

National Natural Science Foundation of China 81873564
6 · The paper itself

Abstract

Primary biliary cholangitis (PBC) is an autoimmune liver disease, mainly characterized by chronic progressive cholestasis. The root cause of PBC is the loss of immune tolerance to autoantigen E2 subunit of pyruvate dehydrogenase (PDC-E2). The unique immunobiological characteristics of intrahepatic bile duct epithelial cells make it an active participant in the pathogenesis of PBC. In recent years, the detection rate of PBC has been increasing year by year, but the clinical situation of ursodeoxycholic acid monotherapy has not changed. Therefore, an in-depth understanding of the immune pathogenesis of PBC will help clinicians better prevent and treat diseases.

Indexed as

Autoimmune DiseasesCholangitisLiver Cirrhosis, BiliaryAutoantigensBile Ducts, IntrahepaticEpithelial CellsHumansAutoantigensImmunopathogenesisIntrahepatic biliary epithelial cellsPrimary biliary cholangitis

Identifiers

PMID34225423
PMCPMC12814045
OpenAlexW3181886933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.