ArticleOphthalmology. Retina2022
Pyramidal Inflammatory Deposits of the Retinal Pigment Epithelium and Outer Retina in Ocular Syphilis.
Article in Ophthalmology. Retina, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Putative mechanisms of ocular inflammation in syphilis.Journal of ophthalmic inflammation and infection · 2026Review
- Genome-sequencing of ocular fluid in a patient with syphilitic uveitis: Strain identification and antimicrobial resistance detection.American journal of ophthalmology case reports · 2026Article
- Clinical outcomes of ocular syphilis within the Great Plains region: potential syndemic impact of methamphetamine use.Eye (London, England) · 2025Observational
- Syphilis and the Eye: Clinical Features, Diagnostic Challenges, and Evolving Therapeutic Paradigms.Pathogens (Basel, Switzerland) · 2025Review
- Ocular vs neurosyphilis. are they the same? A guide to investigation and management.Eye (London, England) · 2024Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo evaluate the role of OCT in the diagnosis of uveitis secondary to syphilis.
designConsecutive, retrospective case series.
participantsAll patients 18 years of age or older with ocular syphilis from 2 tertiary referral centers.
methodsAll patients who were diagnosed with intermediate uveitis, posterior uveitis, or panuveitis secondary to syphilis were included in the study (40 patients representing a total of 62 eyes) to identify important imaging features to aid in diagnosis. Patients underwent confirmatory serologic testing, OCT imaging, and dilated examination by a uveitis specialist.
main outcome measureHyperreflective retinal lesions on OCT.
resultsThe mean age of the study population was 42.9 ± 12.16 years. Forty-five percent of the eyes included in this study harbored hyperreflective pyramidal lesions of the outer retina and retinal pigment epithelium on OCT. Fifty-four percent of eyes with these imaging findings did not show a placoid retinal lesion on examination. Sixty-eighty percent of the described outer retinal lesions on OCT resolved after treatment for syphilis. Visual acuity ranged from normal (20/20) to no light perception, with a mean of 20/43 at diagnosis, and improved significantly to a mean visual acuity of 20/26 after treatment (P < 0.05). Vision-threatening complications were seen in less than 5% of eyes and included both treatable and irreversible causes of vision loss, including retinal detachment, cystoid macular edema, and optic neuropathy.
conclusionsPatients treated for uveitis secondary to syphilis achieve good visual recoveries. Outer retinal lesions seen on OCT are common and can serve as an additional imaging finding of the disease.
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