Evidence map›Paper›PMID 34224917›Full record

ArticleMolecular metabolism2021

From type 1 diabetes biology to therapy: The Human Islet Research Network.

John S Kaddis, Layla Rouse, Audrey V Parent, Diane C Saunders, Anath Shalev, Cherie L Stabler, Doris A Stoffers, Bridget K Wagner, Joyce C Niland

Open access · goldAbstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

John S KaddisDepartment of Diabetes and Cancer Discovery Science, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA, USA. Electronic address: jkaddis@coh.org.
Layla RouseDepartment of Diabetes and Cancer Discovery Science, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Audrey V ParentDiabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Diane C SaundersDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Anath ShalevComprehensive Diabetes Center, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, AL, USA.
Cherie L StablerJ. Crayton Pruitt Family, Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.
Doris A StoffersInstitute for Diabetes, Obesity, and Metabolism and Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Bridget K WagnerChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.
Joyce C NilandDepartment of Diabetes and Cancer Discovery Science, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Beckman Research InstituteBroad Institute · USCity of Hope · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Florida · USUniversity of Pennsylvania · USVanderbilt University Medical Center · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Penn integrated Human Pancreas procurement and Analysis ProgramUC4DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R, FELDMAN, MICHAEL D · 2016 to 2020
$17.8M
Renewal of the Human Islet Research Enhancement Center (HIREC) for the Type-1-Diabetes-Focused Human Islet Research Network (HIRN).U24DK104162 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI John S. Kaddis, Joyce Carol Niland · 2019 to 2026
$12.3M
Modeling autoimmune pathogenesis and beta cell destruction by T1D immune systemsU01DK123559 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANDERSON, MARK S, PARENT, AUDREY · 2019 to 2023
$4.3M
One-compound, one-islet: A high-throughput platform for small-molecule discoveryU01DK123717 · NIDDK · BROAD INSTITUTE, INC. · PI KULKARNI, ROHIT N., WAGNER, BRIDGET K · 2019 to 2022
$3.1M
Engineering a Human Microphysiological System for the Characterization of Islet-Immune InteractionsUH3DK122638 · NIDDK · UNIVERSITY OF FLORIDA · PI AGARWAL, ASHUTOSH, BRUSKO, TODD MICHAEL · 2021 to 2023
$3.0M
Development of an early diagnostic biomarker and novel treatment strategy for T1DU01DK120379 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SHALEV, ANATH · 2018 to 2021
$2.2M
Engineering a Human Microphysiological System for the Characterization of Islet-Immune InteractionsUG3DK122638 · NIDDK · UNIVERSITY OF FLORIDA · PI AGARWAL, ASHUTOSH, BRUSKO, TODD MICHAEL · 2019 to 2020
$2.1M
NIDDK NIH HHS P30 DK079626NIDDK NIH HHS U01 DK120379NIDDK NIH HHS U01 DK123559NIDDK NIH HHS U01 DK123717NIDDK NIH HHS U24 DK104162NIDDK NIH HHS UC4 DK112217NIDDK NIH HHS UG3 DK122638NIDDK NIH HHS UH3 DK122638
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Diabetes Mellitus, Type 1HumansInsulin-Secreting CellsBeta-cell biologyHuman IsletImmunologyType 1 Diabetes

Identifiers

PMID34224917
PMCPMC8711046
OpenAlexW3179580216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.