ArticleProceedings of the National Academy of Sciences of the United States of America1988
Structural conservation among three homologous introns of bacteriophage T4 and the group I introns of eukaryotes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58 citing papers in PubMed, 119 citations in OpenAlex.
- The activity, divergence, and evolutionary degradation of modern-day homing endonucleases and behavior of their reconstructed ancestors.Nucleic acids research · 2026Article
- Refining Mitochondrial Intron Classification With ERPIN: Identification Based on Conservation of Sequence Plus Secondary Structure Motifs.Frontiers in microbiology · 2022Article
- Optimized Loopable Translation as a Platform for the Synthesis of Repetitive Proteins.ACS central science · 2021Article
- Perpetuating the homing endonuclease life cycle: identification of mutations that modulate and change I-TevI cleavage preference.Nucleic acids research · 2016Article
- Article
- A homing endonuclease and the 50-nt ribosomal bypass sequence of phage T4 constitute a mobile DNA cassette.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Learning to live together: mutualism between self-splicing introns and their hosts.BMC biology · 2011Review
- Mobile DNA elements in T4 and related phages.Virology journal · 2010Review
- Social networking between mobile introns and their host genes.Molecular microbiology · 2010Article
- Molecular evolution of mitochondrial introns in the liverwort Marchantia polymorpha.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2008Article
- Self-splicing of the bacteriophage T4 group I introns requires efficient translation of the pre-mRNA in vivo and correlates with the growth state of the infected bacterium.Journal of bacteriology · 2007Article
- Genomic organization and molecular analysis of virulent bacteriophage 2972 infecting an exopolysaccharide-producing Streptococcus thermophilus strain.Applied and environmental microbiology · 2005Article
- Bacteriophage T4 genome.Microbiology and molecular biology reviews : MMBR · 2003Review
- Barriers to intron promiscuity in bacteria.Journal of bacteriology · 2000Review
- Intronic GIY-YIG endonuclease gene in the mitochondrial genome of Podospora curvicolla: evidence for mobility.Nucleic acids research · 2000Article
- Widespread distribution of a group I intron and its three deletion derivatives in the lysin gene of Streptococcus thermophilus bacteriophages.Journal of virology · 2000Article
- Intron homing with limited exon homology. Illegitimate double-strand-break repair in intron acquisition by phage t4.Genetics · 1999Article
- Influence of specific mutations on the thermal stability of the td group I intron in vitro and on its splicing efficiency in vivo: a comparative study.RNA (New York, N.Y.) · 1999Article
- Characterization of rbcL group IA introns from two colonial volvocalean species (Chlorophyceae).Plant molecular biology · 1998Article
- Non-canonical inteins.Nucleic acids research · 1998Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
Three group I introns of bacteriophage T4 have been compared with respect to their sequence and structural properties. The introns include the td intervening sequence, as well as the two newly described introns in the nrdB and sunY genes of T4. The T4 introns are very closely related, containing phylogenetically conserved sequence elements that allow them to be folded into a core structure that is characteristic of eukaryotic group IA introns. Similarities extend outward to the exon sequences surrounding the three introns. All three introns contain open reading frames (ORFs). Although the intron ORFs are not homologous and occur at different positions, all three ORFs are looped-out of the structure models, with only the 3' ends of each of the ORFs extending into the secondary structure. This arrangement invites interesting speculations on the regulation of splicing by translation. The high degree of similarity between the T4 introns and the eukaryotic group I introns must reflect a common ancestry, resulting either from vertical acquisition of a primordial RNA element or from horizontal transfer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.