ArticleProceedings of the National Academy of Sciences of the United States of America1988
Characterization of a mammalian smooth muscle myosin heavy chain cDNA clone and its expression in various smooth muscle types.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 116 citations in OpenAlex.
- A New AutosomalArteriosclerosis, thrombosis, and vascular biology · 2023Article
- Increased atherosclerotic plaque in AOC3 knock-out in ApoEFrontiers in cardiovascular medicine · 2022Article
- Loss of smooth muscle myosin heavy chain results in the bladder and stomach developing lesion during foetal development in mice.Journal of genetics · 2018Article
- Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.Pharmacological reviews · 2016Review
- Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contraction and results in postnatal death in mice.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Regulation of smooth muscle phenotype.Current atherosclerosis reports · 2003Review
- Smooth-muscle myosin heavy-chain isoform expression in bladder-outlet obstruction.World journal of urology · 1996Article
- Tissue-specific and developmentally regulated alternative splicing of a visceral isoform of smooth muscle myosin heavy chain.Nucleic acids research · 1993Article
- Isolation and cloning of Omp alpha, a coiled-coil protein spanning the periplasmic space of the ancestral eubacterium Thermotoga maritima.The EMBO journal · 1992Article
- Role of the COOH-terminal nonhelical tailpiece in the assembly of a vertebrate nonmuscle myosin rod.The Journal of cell biology · 1992Article
- Characterization of a mammalian smooth muscle myosin heavy-chain gene: complete nucleotide and protein coding sequence and analysis of the 5' end of the gene.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Thrombin-stimulated events in cultured vascular smooth-muscle cells.The Biochemical journal · 1991Article
- Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Monoclonal antibodies detect and stabilize conformational states of smooth muscle myosin.The Journal of cell biology · 1989Article
- Cloning of the cDNA encoding the myosin heavy chain of a vertebrate cellular myosin.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Expression and DNA sequence analysis of a human embryonic skeletal muscle myosin heavy chain gene.Nucleic acids research · 1989Article
- The distribution of heavy-chain isoforms of myosin in airways smooth muscle from adult and neonate humans.The Biochemical journal · 1989Article
- The expression of sarcomeric muscle-specific contractile protein genes in BC3H1 cells: BC3H1 cells resemble skeletal myoblasts that are defective for commitment to terminal differentiation.The Journal of cell biology · 1989Article
- Phosphorylatable serine residues are located in a non-helical tailpiece of a catch muscle myosin.Journal of muscle research and cell motility · 1988Article
- Different ratio of myosin heavy chain isoforms in arterial smooth muscle of spontaneously hypertensive rats.Basic research in cardiologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A cDNA clone, SMHC-29, encoding the light meromyosin of smooth muscle myosin heavy chain (MHC), was isolated from a rabbit uterus cDNA library constructed in phage lambda gt11. This smooth muscle MHC cDNA demonstrates significant nucleotide and amino acid sequence homologies with known sarcomeric MHC genes from rabbit, rat skeletal, and nematode body wall myosin, and even with nonmuscle MHC gene from a slime mold (Dictyostelium discoideum), suggesting that smooth muscle, striated muscle, and nonmuscle MHC genes diverged from a common ancestor. The deduced amino acid sequences of the smooth muscle light meromyosin show very similar periodic distributions of hydrophobic and charged residues as found for the light meromyosin of striated muscle MHCs together with a high potential for alpha-helical formation, indicating an alpha-helical coiled-coil structure for the smooth muscle light meromyosin sequences. Furthermore, S1 nuclease mapping has revealed that this smooth muscle MHC gene for SMHC-29 is specifically expressed in smooth muscles of vascular and nonvascular types but not in the striated muscles or nonmuscle cells.
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